GO_Term_name mitochondrial genome maintenance reproduction plasma membrane urea cycle negative regulation of transcription from RNA polymerase II promoter MAPKKK cascade nucleotide binding protein binding DNA secondary structure binding intracellular cell fraction magnesium ion binding cyclin-dependent protein kinase holoenzyme complex syncytium formation by plasma membrane fusion cell morphogenesis cell morphogenesis involved in differentiation nucleic acid binding transcription factor activity entry into host skeletal system development calcium ion binding ciliary or flagellar motility ovulation from ovarian follicle metabolic process osteoblast differentiation peptide receptor activity eye development temperature homeostasis fever generation behavioral fear response formation of primary germ layer mesoderm formation mesodermal cell fate commitment stress fiber establishment of planar polarity morphogenesis of a polarized epithelium cell activation B cell homeostasis phosphatidylserine binding mesonephros development epithelial to mesenchymal transition endothelial cell development regulation of protein phosphorylation lymph vessel development sprouting angiogenesis cell migration involved in sprouting angiogenesis columnar/cuboidal epithelial cell differentiation lens morphogenesis in camera-type eye behavioral defense response mast cell activation involved in immune response immune system process mast cell mediated immunity germinal center formation immune system development leukocyte differentiation regulation of immune system process peptide secretion regulation of peptide secretion regulation of myeloid leukocyte mediated immunity generation of a signal involved in cell-cell signaling regionalization developmental process involved in reproduction positive regulation of systemic arterial blood pressure outflow tract morphogenesis endothelium development cardiac septum development ventricular septum development metanephros morphogenesis epithelial cell morphogenesis axis elongation neural retina development molecular_function nucleic acid binding DNA binding sequence-specific DNA binding transcription factor activity RNA polymerase II transcription factor activity cytoplasmic sequestering of transcription factor membrane MHC class II protein complex catalytic activity cytoskeleton organization secretion acyl-CoA dehydrogenase activity adenosine deaminase activity adenylate cyclase activity arylsulfatase activity carbonate dehydratase activity cyclic-nucleotide phosphodiesterase activity 3-5-cyclic-nucleotide phosphodiesterase activity 3-5-cyclic-AMP phosphodiesterase activity diacylglycerol kinase activity apoptosis dipeptidase activity vacuole fatty acid synthase activity receptor binding cell adhesion long-chain fatty acid-CoA ligase activity ribonuclease P activity exodeoxyribonuclease activity tRNA-specific ribonuclease activity cytosol polypeptide N-acetylgalactosaminyltransferase activity protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity GABA-A receptor activity Wnt receptor activity Wnt receptor signaling pathway Wnt receptor signaling pathway- calcium modulating pathway ionotropic glutamate receptor activity neuropeptide Y receptor activity transmembrane receptor protein tyrosine phosphatase activity ephrin receptor activity signal transduction transforming growth factor beta receptor activity death receptor activity low-density lipoprotein receptor activity transmembrane receptor protein tyrosine kinase signaling pathway intracellular signal transduction transforming growth factor beta receptor- cytoplasmic mediator activity small GTPase regulator activity guanyl-nucleotide exchange factor activity ARF guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity GTPase inhibitor activity ephrin receptor binding integral to plasma membrane platelet-derived growth factor receptor binding transporter activity ion channel activity intracellular ligand-gated ion channel activity excitatory extracellular ligand-gated ion channel activity extracellular-glutamate-gated ion channel activity inward rectifier potassium channel activity voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity cation channel activity calcium channel activity potassium channel activity transmembrane transporter activity sodium:potassium-exchanging ATPase activity inorganic anion exchanger activity binding metal ion binding ATP binding phospholipid binding phosphatidylinositol-4-5-bisphosphate binding phosphatidylinositol-3-4-5-trisphosphate binding cellular_component proteinaceous extracellular matrix cell soluble fraction insoluble fraction nucleus cytoplasm nucleolus mitochondrial inner membrane presequence translocase complex vacuolar lumen Golgi apparatus cytoskeleton kinesin complex voltage-gated calcium channel complex adherens junction cell-substrate adherens junction focal adhesion mannose metabolic process aminoglycan catabolic process glycosaminoglycan catabolic process succinate metabolic process nucleobase- nucleoside- nucleotide and nucleic acid metabolic process cGMP biosynthetic process GTP catabolic process mismatch repair transcription- DNA-dependent regulation of transcription- DNA-dependent regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase III promoter transcription from RNA polymerase II promoter protein modification process protein phosphorylation arginine metabolic process phosphagen metabolic process creatine metabolic process lipid binding sphingomyelin metabolic process glucocorticoid biosynthetic process porphyrin biosynthetic process heme biosynthetic process phosphorus metabolic process phosphate metabolic process nitrogen compound metabolic process transport ion transport cation transport potassium ion transport metal ion transport cellular ion homeostasis cellular metal ion homeostasis Golgi to plasma membrane transport induction of apoptosis cellular component movement substrate-dependent cell migration chemotaxis syncytium formation response to stress hyperosmotic response organelle organization endoplasmic reticulum organization regulation of S phase of mitotic cell cycle synapsis cell communication homophilic cell adhesion establishment of tissue polarity cell surface receptor linked signaling pathway enzyme linked receptor protein signaling pathway receptor guanylyl cyclase signaling pathway signal complex assembly transforming growth factor beta binding G-protein coupled receptor protein signaling pathway muscarinic acetylcholine receptor signaling pathway gamma-aminobutyric acid signaling pathway glutamate signaling pathway intracellular protein kinase cascade activation of JUN kinase activity small GTPase mediated signal transduction Ras protein signal transduction Rho protein signal transduction cell-cell signaling synaptic transmission neuron-neuron synaptic transmission synaptic transmission- cholinergic multicellular organismal development insemination anatomical structure morphogenesis embryo development blastoderm segmentation gastrulation segment specification pattern specification process organ morphogenesis ectoderm development nervous system development axonogenesis axon guidance synapse assembly central nervous system development brain development sensory organ development mesoderm development heart development myoblast fusion sex determination behavior mating behavior grooming behavior adult walking behavior feeding behavior beta-catenin binding neuron recognition motor axon guidance enzyme activator activity glutamate receptor activity voltage-gated potassium channel complex axon cargo transport cytoskeletal protein binding cytoskeletal adaptor activity biological_process neuropeptide receptor activity phosphatidate phosphatase activity ferric iron binding glucocorticoid metabolic process cell death programmed cell death zinc ion binding cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway cation transmembrane transporter activity ionotropic glutamate receptor complex sulfuric ester hydrolase activity glycine binding peptide receptor activity- G-protein coupled potassium-transporting ATPase activity cAMP-dependent protein kinase regulator activity induction of apoptosis by extracellular signals induction of apoptosis via death domain receptors small protein activating enzyme activity identical protein binding caspase activator activity DNA N-glycosylase activity biosynthetic process macromolecule biosynthetic process aspartate family amino acid catabolic process serine family amino acid catabolic process vitamin biosynthetic process nucleoside triphosphate metabolic process nucleoside triphosphate catabolic process purine nucleoside triphosphate catabolic process purine ribonucleotide catabolic process nucleotide catabolic process ribonucleoside triphosphate catabolic process purine ribonucleoside triphosphate catabolic process pyrimidine deoxyribonucleotide metabolic process glycolipid biosynthetic process ribonucleotide catabolic process deoxyribonucleotide metabolic process deoxyribonucleotide catabolic process 2-deoxyribonucleotide metabolic process NAD biosynthetic process response to external stimulus response to salt stress response to endogenous stimulus response to hormone stimulus hormone-mediated signaling pathway SCF ubiquitin ligase complex regulation of biosynthetic process negative regulation of biosynthetic process positive regulation of biosynthetic process negative regulation of metabolic process positive regulation of metabolic process hormone transport anterior/posterior axis specification dorsal/ventral axis specification anterior/posterior pattern formation regulation of signal transduction negative regulation of signal transduction cellular process response to extracellular stimulus response to organic substance response to inorganic substance response to iron ion production of miRNAs involved in gene silencing by miRNA regulation of G2/M transition of mitotic cell cycle exit from mitosis gene expression regulation of gene expression stress granule positive regulation of phospholipase activity Hsp90 protein binding regulation of gene-specific transcription from RNA polymerase II promoter negative regulation of gene-specific transcription from RNA polymerase II promoter regulation of macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process negative regulation of macromolecule biosynthetic process regulation of glycoprotein biosynthetic process positive regulation of macromolecule metabolic process negative regulation of macromolecule metabolic process posttranscriptional regulation of gene expression developmental programmed cell death positive regulation of gene expression negative regulation of gene expression epithelial cell migration regulation of epithelial cell migration regulation of cell communication negative regulation of cell communication positive regulation of collagen metabolic process regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition positive regulation of cell development regulation of cell morphogenesis involved in differentiation positive regulation of cell morphogenesis involved in differentiation negative regulation of cell morphogenesis involved in differentiation regulation of cholesterol efflux lipid localization regulation of cell death positive regulation of cell death positive regulation of neuron projection development induction of programmed cell death trans-Golgi network transport vesicle membrane oligodendrocyte development glutamate secretion regulation of glutamate secretion regulation of norepinephrine secretion response to purine-containing compound heparan sulfate proteoglycan biosynthetic process anchored to membrane coreceptor activity ion transmembrane transporter activity phosphate transmembrane transporter activity neutral amino acid transmembrane transporter activity cofactor transporter activity sterol transporter activity channel activity ligand-gated ion channel activity anion:anion antiporter activity fatty acid ligase activity monovalent inorganic cation transport ferric iron transport bicarbonate transport neutral amino acid transport amine transport norepinephrine transport cofactor transport drug transport coenzyme A metabolic process pantothenate metabolic process dystrophin-associated glycoprotein complex cytoplasmic membrane-bounded vesicle cellular component organization detection of bacterium RNA metabolic process positive regulation of nucleobase- nucleoside- nucleotide and nucleic acid metabolic process positive regulation of lipid biosynthetic process AMP binding death kinase activity phosphorylation basolateral plasma membrane regulation of apoptosis cell-cell adhesion acylglycerol O-acyltransferase activity posttranscriptional gene silencing cell migration apoptotic protease activator activity transcription repressor activity histone phosphorylation histone demethylation Rac protein signal transduction oxidoreductase activity- acting on the CH-CH group of donors- oxygen as acceptor oxidoreductase activity- acting on paired donors- with incorporation or reduction of molecular oxyge oxidoreductase activity- oxidizing metal ions transferase activity transferase activity- transferring phosphorus-containing groups phosphotransferase activity- alcohol group as acceptor hydrolase activity hydrolase activity- acting on carbon-nitrogen (but not peptide) bonds hydrolase activity- acting on carbon-nitrogen (but not peptide) bonds- in linear amidines exodeoxyribonuclease activity- producing 5-phosphomonoesters GABA receptor activity ceramidase activity purine nucleotide binding Golgi transport complex cholesterol transporter activity enzyme binding response to arsenic-containing substance Wnt-protein binding vinculin binding peptidyl-arginine modification GMP binding reproductive behavior transmembrane receptor protein phosphatase activity transmembrane receptor protein kinase activity carbohydrate kinase activity carbohydrate phosphatase activity nucleoside kinase activity regulation of lipid metabolic process regulation of nucleobase- nucleoside- nucleotide and nucleic acid metabolic process regulation of phosphate metabolic process regulation of metabolic process transmission of nerve impulse pentose metabolic process nicotinamide nucleotide biosynthetic process pyridine nucleotide biosynthetic process protein metabolic process response to cadmium ion kinesin binding kinase binding protein kinase binding protein domain specific binding spinal cord development cell differentiation in spinal cord dorsal spinal cord development ventral spinal cord development spinal cord motor neuron differentiation diencephalon development telencephalon development pallium development subpallium development cranial nerve morphogenesis striatum development limbic system development hippocampus development forebrain regionalization olfactory bulb interneuron differentiation cerebral cortex neuron differentiation rostrocaudal neural tube patterning central nervous system neuron axonogenesis pituitary gland development neurogenesis negative regulation of cell-cell adhesion reproductive process regulation of anatomical structure morphogenesis regulation of cell morphogenesis biological adhesion gland morphogenesis passive transmembrane transporter activity substrate-specific transmembrane transporter activity voltage-gated channel activity ligand-gated channel activity gated channel activity substrate-specific channel activity voltage-gated cation channel activity substrate-specific transporter activity signal transduction via phosphorylation event signaling regulation of signaling negative regulation of signaling signal release cell projection organization cell junction cell-substrate junction peptide hormone secretion insulin secretion hemopoiesis clathrin coat of trans-Golgi network vesicle clathrin coat of coated pit manganese ion binding cell differentiation platelet activation neuron differentiation heparan sulfate proteoglycan metabolic process macrophage differentiation lipoprotein particle receptor activity enzyme regulator activity entry into host cell LRR domain binding clathrin binding outer membrane-bounded periplasmic space external encapsulating structure cell envelope axon dendrite positive regulation of bone mineralization estrogen receptor signaling pathway transcription regulator activity male genitalia development receptor activator activity cyclic nucleotide binding cAMP binding cGMP binding adenyl nucleotide binding neurotransmitter receptor activity Rac GTPase activator activity GTPase regulator activity sequestering of triglyceride regulation of cGMP metabolic process regulation of cGMP biosynthetic process prostate gland development regulation of granulocyte differentiation thyroid gland development replisome forebrain development midbrain development regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway mismatched DNA binding response to caffeine extracellular matrix dsRNA fragmentation regulation of histone modification negative regulation of histone modification positive regulation of histone modification axon regeneration SCF-dependent proteasomal ubiquitin-dependent protein catabolic process neuron projection development SNARE complex intrinsic to plasma membrane retinal ganglion cell axon guidance regulation of cellular metabolic process negative regulation of cellular metabolic process positive regulation of cellular metabolic process regulation of cellular biosynthetic process negative regulation of cellular biosynthetic process positive regulation of cellular biosynthetic process regulation of protein modification process cytoplasmic vesicle L-ascorbic acid binding microvillus membrane ruffle organization hemidesmosome assembly negative regulation of neurological system process protein destabilization heat generation regulation of heat generation positive regulation of heat generation membrane-enclosed lumen nuclear lumen vesicle membrane-bounded vesicle regulation of fatty acid beta-oxidation regulation of TOR signaling cascade ARF protein signal transduction response to magnesium ion response to food regulation of response to food regulation of appetite regulation of response to extracellular stimulus negative regulation of response to extracellular stimulus regulation of response to nutrient levels negative regulation of response to nutrient levels regulation of synaptic transmission- GABAergic phosphatidylinositol-3-phosphate binding regulation of cellular protein metabolic process mismatch repair complex regulation of Ras GTPase activity regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation regulation of hormone metabolic process response to estradiol stimulus positive regulation of lipid transport regulation of sterol transport regulation of cholesterol transport melanosome localization establishment of melanosome localization melanosome transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity stereocilium stereocilium bundle actin filament bundle demethylase activity histone demethylase activity regulation of Cdc42 protein signal transduction multicellular organismal process developmental process multicellular organism reproduction ribonucleotide binding purine ribonucleotide binding adenyl ribonucleotide binding gene-specific transcription from RNA polymerase II promoter negative regulation of gene-specific transcription regulation of gene-specific transcription neuron projection membrane integral to mitochondrial membrane interleukin-4 production regulation of interleukin-4 production RNA biosynthetic process glomerulus development response to insulin stimulus cellular response to insulin stimulus cellular response to hormone stimulus regulation of localization regulation of activin receptor signaling pathway secretion by cell collagen biosynthetic process regulation of collagen biosynthetic process positive regulation of collagen biosynthetic process cellular component morphogenesis cell part morphogenesis macromolecular complex regulation of mast cell activation involved in immune response tetrapyrrole biosynthetic process sarcoplasmic reticulum membrane myeloid cell apoptosis regulation of myeloid cell apoptosis multicellular organismal reproductive behavior T cell differentiation in thymus regulation of T cell differentiation in thymus regulation of GTP catabolic process negative regulation of steroid hormone receptor signaling pathway regulation of estrogen receptor signaling pathway V(D)J recombination response to ATP regulation of S phase transferrin transport regulation of mammary gland epithelial cell proliferation positive regulation of kinase activity positive regulation of tissue remodeling regulation of toll-like receptor signaling pathway ion transmembrane transport adherens junction organization macromolecular complex remodeling protein-lipid complex remodeling plasma lipoprotein particle remodeling triglyceride-rich lipoprotein particle remodeling very-low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling plasma lipoprotein particle assembly low-density lipoprotein particle clearance protein localization at cell surface steroid esterification sterol esterification cholesterol esterification substrate adhesion-dependent cell spreading heparan sulfate sulfotransferase activity cellular response to heat cellular nitrogen compound metabolic process cellular response to UV cellular macromolecule biosynthetic process nucleobase- nucleoside- nucleotide and nucleic acid catabolic process nucleobase- nucleoside and nucleotide catabolic process ion channel complex cation channel complex calcium channel complex potassium channel complex regulation of Rho protein signal transduction regulation of histone acetylation genitalia morphogenesis embryonic hindlimb morphogenesis tail morphogenesis hindlimb morphogenesis social behavior posttranscriptional gene silencing by RNA gene silencing by miRNA synaptic transmission- glutamatergic glutamate receptor binding ionotropic glutamate receptor binding long-chain fatty-acyl-CoA metabolic process fatty-acyl-CoA metabolic process long-chain fatty-acyl-CoA biosynthetic process thioester biosynthetic process non-canonical Wnt receptor signaling pathway purinergic receptor signaling pathway multicellular organismal signaling purine ribonucleoside triphosphate binding locomotion positive regulation of multicellular organism growth chemokine biosynthetic process wound healing regulation of catecholamine metabolic process interleukin-2 biosynthetic process regulation of cell proliferation neurotransmitter binding heme metabolic process response to chemical stimulus establishment of planar polarity of embryonic epithelium MHC protein binding phosphate binding regulation of fatty acid biosynthetic process regulation of phosphorylation taxis water-soluble vitamin biosynthetic process ribonucleoside catabolic process regulation of odontogenesis neuron maturation phosphoric ester hydrolase activity homeostatic process fear response periplasmic space chylomicron actomyosin muscle cell differentiation DNA damage response- signal transduction by p53 class mediator resulting in induction of apoptosis histone methyltransferase activity (H3-K4 specific) negative regulation of transcription factor import into nucleus cell projection neuron projection camera-type eye development positive regulation of apoptosis regulation of programmed cell death positive regulation of programmed cell death positive regulation of catalytic activity regulation of GTPase activity regulation of Cdc42 GTPase activity receptor clustering tumor necrosis factor binding ion binding cation binding macromolecule metabolic process nucleoside salvage myelin sheath organelle membrane-bounded organelle non-membrane-bounded organelle intracellular organelle intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle organelle lumen protein complex laminin complex regulation of potassium ion transport regulation of leukocyte degranulation mast cell degranulation regulation of mast cell degranulation phosphatidylinositol-3-4-bisphosphate binding proteoglycan binding heparan sulfate proteoglycan binding steroid hormone mediated signaling pathway macromolecule modification bHLH transcription factor binding response to peptide hormone stimulus regulation of blood vessel endothelial cell migration positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration regulation of kinase activity regulation of lipid kinase activity insulin receptor substrate binding sequence-specific DNA binding regulation of respiratory gaseous exchange nose development tongue development nuclear replication fork nuclear replisome amide biosynthetic process reverse cholesterol transport regulation of digestive system process regulation of endocrine process positive regulation of molecular function cellular metabolic process primary metabolic process cellular biosynthetic process positive regulation of multicellular organismal metabolic process cellular macromolecule metabolic process cellular protein metabolic process cellular nitrogen compound catabolic process small molecule metabolic process small molecule catabolic process small molecule biosynthetic process organelle part intracellular part membrane part nuclear part cytoplasmic part intracellular organelle part synapse part plasma membrane part external encapsulating structure part cell projection part cell part T cell selection thymic T cell selection regulation of chemokine biosynthetic process regulation of interleukin-2 biosynthetic process positive regulation of interleukin-2 biosynthetic process pronucleus meiotic chromosome segregation cell fate commitment synapse postsynaptic membrane phagocytic vesicle endothelial cell differentiation regulation of B cell differentiation negative regulation of T cell differentiation regulation of cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of fat cell differentiation negative regulation of lymphocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation regulation of macrophage differentiation regulation of myoblast differentiation regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of fatty acid biosynthetic process positive regulation of cyclin-dependent protein kinase activity positive regulation of axon extension positive regulation of blood pressure positive regulation of ossification negative regulation of endocytosis positive regulation of lipid metabolic process regulation of protein kinase activity positive regulation of protein kinase activity negative regulation of smoothened signaling pathway positive regulation of survival gene product expression negative regulation of transcription- DNA-dependent positive regulation of transcription- DNA-dependent negative regulation of fatty acid metabolic process positive regulation of fatty acid metabolic process negative regulation of mitotic cell cycle negative regulation of nucleobase- nucleoside- nucleotide and nucleic acid metabolic process positive regulation of steroid metabolic process positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development cGMP metabolic process pyrimidine nucleoside biosynthetic process positive regulation of fatty acid oxidation urate metabolic process heterocycle metabolic process ceramide biosynthetic process regulation of Ras protein signal transduction regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway gamma-delta T cell activation heterocycle catabolic process entry of virus into host cell protein autophosphorylation lipid phosphorylation phosphatidylinositol phosphorylation hormone secretion regulation of hormone secretion ion homeostasis transition metal ion binding fatty-acyl-CoA biosynthetic process protein dimerization activity vesicle transport along microtubule 3-5-cyclic-GMP phosphodiesterase activity nerve growth factor receptor signaling pathway quinone binding regulation of developmental pigmentation activin binding norepinephrine secretion response to pain mesoderm morphogenesis mesodermal cell differentiation paraxial mesoderm development platelet-derived growth factor binding cell development perinuclear region of cytoplasm organ development positive regulation of biological process negative regulation of biological process positive regulation of cellular process negative regulation of cellular process hemopoietic or lymphoid organ development spleen development digestive tract morphogenesis embryonic digestive tract morphogenesis embryonic organ morphogenesis digestive tract development embryonic organ development regulation of response to stimulus negative regulation of response to stimulus camera-type eye morphogenesis embryonic morphogenesis multicellular organismal reproductive process positive regulation of developmental growth neuron fate commitment neuron fate specification neuron development cell morphogenesis involved in neuron differentiation generation of neurons embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis skeletal system morphogenesis embryonic skeletal system development tissue morphogenesis system development gland development regulation of skeletal muscle fiber development genitalia development neuron projection morphogenesis erythrocyte development regulation of axon extension involved in axon guidance anatomical structure development cell projection morphogenesis cellular developmental process cell motility chemical homeostasis chondroitin sulfate proteoglycan biosynthetic process chemokine metabolic process regulation of neurogenesis regulation of axonogenesis positive regulation of axonogenesis regulation of biological process regulation of catalytic activity regulation of developmental process regulation of cellular process regulation of synapse structure and activity negative regulation of synaptic transmission regulation of synapse organization B cell receptor signaling pathway neuromuscular process controlling balance response to stimulus negative chemotaxis negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis regulation of small GTPase mediated signal transduction negative regulation of developmental process positive regulation of developmental process regulation of cellular component organization regulation of nitrogen compound metabolic process negative regulation of nitrogen compound metabolic process positive regulation of nitrogen compound metabolic process regulation of phosphorus metabolic process localization establishment of localization regulation of multicellular organismal process regulation of protein metabolic process regulation of RNA metabolic process negative regulation of RNA metabolic process positive regulation of RNA metabolic process regulation of hydrolase activity regulation of transferase activity positive regulation of transferase activity mitochondrion localization localization within membrane localization of cell cellular response to stimulus entry into cell of other organism involved in symbiotic interaction entry into other organism involved in symbiotic interaction pigment granule localization pigment granule transport establishment of pigment granule localization synaptic transmission- GABAergic negative regulation of amine transport positive regulation of amine transport regulation of nervous system development regulation of synaptogenesis regulation of synaptic transmission- glutamatergic negative regulation of transmission of nerve impulse regulation of telomerase activity movement in host environment movement in environment of other organism involved in symbiotic interaction metal ion homeostasis anion homeostasis transmembrane transport regulation of cardiac muscle contraction digestive system development convergent extension retina morphogenesis in camera-type eye Wnt receptor signaling pathway- planar cell polarity pathway regulation of postsynaptic membrane potential regulation of excitatory postsynaptic membrane potential membrane hyperpolarization regulation of lipase activity positive regulation of lipase activity clathrin sculpted vesicle mesenchymal to epithelial transition regulation of macromolecule metabolic process regulation of cell development cartilage development involved in endochondral bone morphogenesis SMAD protein signal transduction cardiac septum morphogenesis lung epithelium development trachea development epithelial tube branching involved in lung morphogenesis branching involved in prostate gland morphogenesis lung cell differentiation prostate gland morphogenesis prostate glandular acinus development morphogenesis of an epithelial fold morphogenesis of an epithelial bud nucleoside-triphosphatase regulator activity lateral sprouting from an epithelium branch elongation of an epithelium adipose tissue development prostate gland growth prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development epithelial cell proliferation involved in prostate gland development ectodermal placode formation cell fate commitment involved in formation of primary germ layers endocrine hormone secretion kidney morphogenesis cell differentiation involved in kidney development regulation of cartilage development muscle structure development renal tubule development protein-lipid complex assembly biological regulation regulation of biological quality regulation of molecular function intracellular organelle lumen histone lysine demethylation anchoring junction positive regulation of biomineral tissue development chromosome organization involved in meiosis T cell apoptosis regulation of T cell apoptosis thymocyte apoptosis regulation of thymocyte apoptosis NAD+ binding I-SMAD binding R-SMAD binding repressing transcription factor binding production of small RNA involved in gene silencing by RNA cellular response to vitamin cellular response to vitamin A cellular response to retinoic acid cellular response to organic substance cellular response to peptide hormone stimulus cellular response to corticosteroid stimulus cellular response to glucocorticoid stimulus cellular response to fatty acid hemopoietic stem cell proliferation cellular response to oxygen levels cellular response to hypoxia cellular response to radiation cellular response to ionizing radiation cellular response to light stimulus cellular response to endogenous stimulus nBAF complex acyl-CoA biosynthetic process ectodermal placode development ectodermal placode morphogenesis protein-lipid complex subunit organization plasma lipoprotein particle organization cellular component organization or biogenesis cellular component organization or biogenesis at cellular level cellular component organization at cellular level regulation of protein serine/threonine kinase activity cell periphery nephron development nephron epithelium development nephron morphogenesis kidney epithelium development renal vesicle morphogenesis nephron tubule development renal vesicle development nephron epithelium morphogenesis metanephric nephron development metanephric nephron morphogenesis modified amino acid transmembrane transporter activity purine-containing compound metabolic process purine-containing compound catabolic process pyridine-containing compound biosynthetic process pyrimidine-containing compound transmembrane transport regulation of reactive oxygen species metabolic process phosphatidylinositol-3-5-bisphosphate binding regulation of primary metabolic process regulation of peptide transport cochlea development tissue migration epithelium migration regulation of establishment of planar polarity regulation of triglyceride metabolic process positive regulation of triglyceride metabolic process regulation of peptide hormone secretion nucleic acid metabolic process cellular senescence regulation of multicellular organismal development regulation of organ morphogenesis negative regulation of leukocyte apoptosis regulation of cellular macromolecule biosynthetic process negative regulation of cellular macromolecule biosynthetic process regulation of neural precursor cell proliferation positive regulation of neural precursor cell proliferation regulation of fatty acid transport Golgi membrane protein binding transcription factor activity transcription factor binding transcription factor activity ossification regulation of neurotransmitter levels angiogenesis cell growth blood vessel development response to hypoxia in utero embryonic development morphogenesis of a branching structure positive regulation of protein phosphorylation hair follicle development vasculature development glycoprotein binding endochondral ossification morphogenesis of an epithelium chondrocyte differentiation osteoblast development immune effector process myeloid leukocyte differentiation positive regulation of immune system process regulation of leukocyte activation positive regulation of leukocyte activation regulation of immune effector process immune response-regulating cell surface receptor signaling pathway regulation of response to biotic stimulus regulation of humoral immune response heart morphogenesis system process muscle system process circulatory system process heart process cardiac chamber morphogenesis cardiac ventricle morphogenesis cardiac ventricle development amino acid transmembrane transport steroid hormone receptor activity transcription cofactor activity motor activity muscle contraction contractile fiber actin binding protein binding- bridging actin filament binding actin filament bundle assembly actin cytoskeleton organization defense response blood coagulation vesicle-mediated transport metal ion transmembrane transporter activity integral to membrane extracellular region transmembrane receptor protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer activity ligand-dependent nuclear receptor activity receptor signaling protein activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity Rho GTPase activator activity frizzled binding insulin receptor binding integrin binding structural constituent of cytoskeleton collagen amine transmembrane transporter activity neurotransmitter transporter activity cation:amino acid symporter activity calmodulin binding basement membrane integrin complex extracellular space membrane fraction transcription factor complex endocytic vesicle muscle myosin complex microvillus coated pit cell-cell junction cell-cell adherens junction aminoglycan biosynthetic process glycosaminoglycan biosynthetic process energy reserve metabolic process regulation of nucleotide metabolic process purine nucleotide metabolic process purine nucleotide biosynthetic process cAMP biosynthetic process nucleoside phosphate metabolic process sodium ion transport calcium ion transport neurotransmitter transport amino acid transport lipid transport endocytosis phagocytosis regulation of striated muscle contraction sensory perception of mechanical stimulus inflammatory response immune response humoral immune response actin filament organization cell-substrate junction assembly growth cell-matrix adhesion negative regulation of cell adhesion receptor tyrosine kinase binding G-protein signaling- coupled to cyclic nucleotide second messenger G-protein signaling- coupled to cAMP nucleotide second messenger activation of adenylate cyclase activity by G-protein signaling pathway activation of adenylate cyclase activity inhibition of adenylate cyclase activity by G-protein signaling pathway negative regulation of adenylate cyclase activity activation of phospholipase C activity dopamine receptor signaling pathway neuropeptide signaling pathway smoothened signaling pathway integrin-mediated signaling pathway calcium-mediated signaling neurotransmitter secretion tissue development neurological system process salivary gland morphogenesis endoderm development muscle organ development excretion hemostasis sensory perception of sound learning or memory locomotory behavior blood circulation regulation of heart contraction synaptic vesicle growth factor activity transcription factor binding sulfotransferase activity UDP-glycosyltransferase activity G-protein coupled amine receptor activity associative learning structural constituent of muscle regulation of cell shape regulation of cell size acetylgalactosaminyltransferase activity cAMP metabolic process fibroblast growth factor receptor signaling pathway epidermis development actin filament-based movement regulation of smoothened signaling pathway nucleotide metabolic process nucleoside monophosphate metabolic process nucleoside monophosphate biosynthetic process nucleotide biosynthetic process cyclic nucleotide metabolic process cyclic nucleotide biosynthetic process response to pH response to biotic stimulus response to wounding response to other organism response to bacterium response to abiotic stimulus embryo development ending in birth or egg hatching regulation of catabolic process negative regulation of catabolic process external side of plasma membrane proximal/distal pattern formation positive regulation of signal transduction cell surface membrane invagination positive regulation of gene-specific transcription from RNA polymerase II promoter positive regulation of phosphorus metabolic process regulation of adenylate cyclase activity involved in G-protein signaling pathway positive regulation of adenylate cyclase activity by G-protein signaling pathway regulation of intracellular protein kinase cascade positive regulation of cell communication positive regulation of cellular carbohydrate metabolic process positive regulation of intracellular protein kinase cascade regulation of hormone levels positive regulation of phospholipase C activity regulation of glucose metabolic process positive regulation of glucose metabolic process anatomical structure formation involved in morphogenesis regulation of metal ion transport endomembrane system vesicle membrane mesenchymal cell development postsynaptic density response to tropane intercalated disc striated muscle tissue development sodium ion transmembrane transporter activity L-amino acid transmembrane transporter activity actin cytoskeleton peptide transport cellular membrane organization apicolateral plasma membrane morphogenesis of embryonic epithelium myosin complex transcription activator activity peptide hormone binding SH3 domain binding peptidyl-tyrosine phosphorylation heterocycle biosynthetic process peptide cross-linking peptidyl-amino acid modification peptidyl-tyrosine modification cytokine-mediated signaling pathway cellular homeostasis second-messenger-mediated signaling cAMP-mediated signaling cyclic-nucleotide-mediated signaling cerebellum development cerebellar cortex morphogenesis cerebellar cortex formation olfactory bulb development forebrain generation of neurons forebrain neuron differentiation dorsal/ventral neural tube patterning neural tube development central nervous system neuron differentiation olfactory lobe development metencephalon development molting cycle process hair cycle process active transmembrane transporter activity ion gated channel activity regulation of transmembrane transporter activity positive regulation of signaling myofibril sarcomere lamellipodium actin filament-based process muscle filament sliding lymphocyte differentiation myeloid cell differentiation coated vesicle clathrin-coated vesicle regulation of cell adhesion integral to Golgi membrane filopodium B cell differentiation extracellular matrix organization T cell differentiation regulation of ossification respiratory tube development lung development adrenal gland development embryonic limb morphogenesis regulation of cell migration positive regulation of cell migration negative regulation of cell migration cytoplasmic vesicle membrane coated vesicle membrane clathrin coated vesicle membrane regulation of cyclic nucleotide metabolic process regulation of cyclic nucleotide biosynthetic process regulation of nucleotide biosynthetic process regulation of cAMP metabolic process regulation of cAMP biosynthetic process cortical cytoskeleton mammary gland development hindbrain development hair follicle morphogenesis regeneration intrinsic to membrane intrinsic to Golgi membrane cell leading edge cell projection membrane regulation of cyclase activity negative regulation of cyclase activity positive regulation of cyclase activity lymphocyte costimulation T cell costimulation regulation of cellular catabolic process regulation of cell projection organization positive regulation of cell projection organization cell-substrate adhesion regulation of neurological system process cellular response to extracellular stimulus A band regulation of response to external stimulus positive regulation of response to external stimulus protein complex binding regulation of ion transmembrane transporter activity response to retinoic acid regulation of cellular component size regulation of actin cytoskeleton organization collagen metabolic process regulation of actin filament-based process myosin filament response to vitamin A axon part actin-myosin filament sliding multicellular organismal response to stress osteoblast proliferation response to cytokine stimulus cell junction assembly cell junction organization regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor nucleobase- nucleoside and nucleotide biosynthetic process nucleobase- nucleoside- nucleotide and nucleic acid biosynthetic process regulation of transmembrane transport regulation of ion transmembrane transport appendage morphogenesis limb morphogenesis embryonic appendage morphogenesis forelimb morphogenesis tube morphogenesis exocrine system development tube development regulation of locomotion negative regulation of locomotion positive regulation of locomotion histone methyltransferase activity T cell activation B cell activation SH2 domain binding response to cocaine tissue regeneration molting cycle positive regulation of phosphorylation sarcolemma regulation of membrane potential hormone metabolic process inner ear morphogenesis mechanoreceptor differentiation hair cycle presynaptic membrane chordate embryonic development neuronal cell body extracellular structure organization stress fiber assembly positive regulation of gene-specific transcription terminal button dendritic spine receptor complex response to alkaloid apical junction complex regulation of ATPase activity protein kinase B signaling cascade blood vessel endothelial cell migration ear development skin development axon terminus regulation of multi-organism process regulation of system process regulation of cellular component biogenesis negative regulation of molecular function multicellular organismal macromolecule metabolic process cellular nitrogen compound biosynthetic process cell-cell contact zone cell body main axon neuron projection terminus neuron spine extracellular matrix part extracellular region part cytoskeletal part Golgi apparatus part cytoplasmic vesicle part contractile fiber part membrane raft cell-cell junction organization leukocyte activation response to ethanol regulation of osteoblast differentiation regulation of adenylate cyclase activity positive regulation of adenylate cyclase activity regulation of angiogenesis regulation of anti-apoptosis positive regulation of carbohydrate metabolic process positive regulation of phosphate metabolic process lymphocyte activation negative regulation of hormone secretion protein heterodimerization activity platelet-derived growth factor receptor signaling pathway focal adhesion assembly lung alveolus development blood vessel morphogenesis response to steroid hormone stimulus embryonic digestive tract development positive regulation of response to stimulus developmental growth epidermis morphogenesis appendage development mesenchymal cell differentiation inner ear development epithelial cell proliferation regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation regulation of defense response to virus regulation of defense response to virus by virus regulation of peptidyl-tyrosine phosphorylation regulation of immune response regulation of synaptic transmission coagulation antigen receptor-mediated signaling pathway regulation of T cell activation regulation of cell activation positive regulation of cell activation positive regulation of T cell activation regulation of body fluid levels cognition leukocyte migration regulation of positive chemotaxis regulation of secretion regulation of transport negative regulation of transport negative regulation of cellular component organization positive regulation of cellular component organization striated muscle cell differentiation positive regulation of muscle cell differentiation release of sequestered calcium ion into cytosol cartilage development regulation of lymphocyte activation positive regulation of lymphocyte activation regulation of cellular component movement negative regulation of cellular component movement positive regulation of cellular component movement regulation of sequestering of calcium ion negative regulation of sequestering of calcium ion regulation of lyase activity positive regulation of lyase activity negative regulation of lyase activity cytosolic calcium ion homeostasis defense response to virus cellular localization establishment of localization in cell multi-organism process regulation of focal adhesion assembly regulation of protein kinase B signaling cascade positive regulation of protein kinase B signaling cascade regulation of transmission of nerve impulse cellular chemical homeostasis palate development heart contraction cardiac muscle contraction canonical Wnt receptor signaling pathway molecular transducer activity binding- bridging inner ear receptor cell differentiation limb development cell chemotaxis regulation of cellular localization bone development cytosolic calcium ion transport calcium ion transport into cytosol lung morphogenesis epithelium development branching involved in salivary gland morphogenesis muscle tissue development respiratory system development developmental growth involved in morphogenesis epithelial tube morphogenesis regulation of canonical Wnt receptor signaling pathway membrane organization somite development actin-mediated cell contraction response to oxygen levels leukocyte proliferation divalent metal ion transport cellular response to chemical stimulus cellular response to cytokine stimulus organic substance transport nitrogen compound transport cellular potassium ion transport potassium ion transmembrane transport cardiovascular system development circulatory system development divalent inorganic cation transport purine-containing compound biosynthetic process regulation of anatomical structure size regulation of cell-substrate junction assembly positive regulation of canonical Wnt receptor signaling pathway regulation of ion homeostasis regulation of cell motility negative regulation of cell motility positive regulation of cell motility activation of MAPK activity response to superoxide response to oxygen radical alternative nuclear mRNA splicing- via spliceosome autophagic vacuole membrane embryonic axis specification neurotransmitter uptake voltage-gated sodium channel complex oxygen transporter activity lysosphingolipid and lysophosphatidic acid receptor activity G-protein chemoattractant receptor activity male germ cell nucleus cell fate determination organ induction myeloid dendritic cell activation pattern binding placenta development maternal placenta development startle response fibronectin binding response to amphetamine morphogenesis of an epithelial sheet response to dietary excess regulation of sodium ion transport desensitization of G-protein coupled receptor protein signaling pathway epithelial cell maturation T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response CD4-positive- alpha-beta T cell differentiation involved in immune response myeloid leukocyte mediated immunity neutrophil mediated immunity antigen processing and presentation of peptide or polysaccharide antigen via MHC class II tolerance induction acute inflammatory response chronic inflammatory response monocyte chemotaxis regulation of acute inflammatory response positive regulation of acute inflammatory response regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of leukocyte chemotaxis positive regulation of B cell mediated immunity regulation of myeloid leukocyte differentiation negative regulation of myeloid leukocyte differentiation negative regulation of peptide secretion regulation of T-helper 1 type immune response positive regulation of immunoglobulin mediated immune response positive regulation of humoral immune response regulation of organ formation cardiac chamber development cardiac atrium morphogenesis cardiac atrium development regulation of membrane depolarization cardiac muscle hypertrophy estradiol 17-beta-dehydrogenase activity guanylate cyclase activity pancreatic ribonuclease activity MAP kinase activity receptor activity nicotinic acetylcholine-activated cation-selective channel activity carbohydrate binding cytokine receptor activity chemokine receptor activity serotonin receptor activity endoplasmic reticulum epidermal growth factor receptor binding insulin-like growth factor receptor binding extracellular ligand-gated ion channel activity gap junction channel activity voltage-gated sodium channel activity anion channel activity chloride channel activity sodium channel activity dicarboxylic acid transmembrane transporter activity neurotransmitter:sodium symporter activity organic acid transmembrane transporter activity secondary active transmembrane transporter activity monovalent cation:hydrogen antiporter activity iron ion binding sequestering of calcium ion sugar binding glycosaminoglycan binding folic acid binding stored secretory granule hemoglobin complex mRNA cap binding complex striated muscle thin filament caveola polysaccharide metabolic process fructose metabolic process alcohol metabolic process regulation of gluconeogenesis regulation of gene expression by genetic imprinting protein monoubiquitination glutamate metabolic process cellular biogenic amine metabolic process catecholamine metabolic process lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process glutathione biosynthetic process phosphate transport anion transport dicarboxylic acid transport cellular calcium ion homeostasis cell volume homeostasis regulation of muscle contraction meiotic prophase I female meiosis regulation of epidermal growth factor receptor activity activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupl elevation of cytosolic calcium ion concentration Notch receptor processing neuromuscular synaptic transmission female gamete generation acrosome reaction adult heart development lymph node development sex differentiation aging response to nutrient blood coagulation- intrinsic pathway visual behavior adult behavior asymmetric protein localization O-methyltransferase activity ferrous iron binding heparin binding regulation of blood pressure determination of adult lifespan adult locomotory behavior sialyltransferase activity gonad development selenium binding transaminase activity anion transmembrane transporter activity organic anion transmembrane transporter activity visual learning lipid biosynthetic process nucleoside monophosphate catabolic process phenylpropanoid metabolic process catechol metabolic process cyclase activity cardioblast differentiation specification of organ identity histone monoubiquitination negative regulation of cell fate commitment positive regulation of heart rate regulation of receptor activity regulation of phospholipase activity regulation of calcium ion transport into cytosol positive regulation of calcium ion transport into cytosol muscle cell apoptosis regulation of muscle cell apoptosis negative regulation of macrophage derived foam cell differentiation positive regulation of mitochondrion organization negative regulation of lipid storage regulation of protein maturation by peptide bond cleavage primary neural tube formation dopamine secretion regulation of dopamine secretion response to organic cyclic compound phasic smooth muscle contraction striated muscle cell proliferation striated muscle hypertrophy potassium ion transmembrane transporter activity chloride transmembrane transporter activity drug transmembrane transporter activity solute:hydrogen antiporter activity calcium:cation antiporter activity solute:sodium symporter activity acetylcholine receptor activity cholesterol binding gas transport monoamine transport organic acid transport organic alcohol transport nucleoside transport dopamine transport synaptic vesicle exocytosis apical plasma membrane peptide hormone processing C-C chemokine receptor activity transferase activity- transferring amino-acyl groups phosphorus-oxygen lyase activity intramolecular transferase activity- phosphotransferases endoribonuclease activity- producing 3-phosphomonoesters endonuclease activity- active with either ribo- or deoxyribonucleic acids and producing 3-phosphomon Rab GTPase binding calcium ion-dependent exocytosis regulation of exocytosis regulation of calcium ion-dependent exocytosis phenol-containing compound metabolic process nucleotide kinase activity regulation of fatty acid metabolic process removal of superoxide radicals synaptosome response to mercury ion vitamin binding immunoglobulin binding inositol phosphate-mediated signaling cytokine binding chemokine binding C-C chemokine binding developmental maturation central nervous system neuron development negative adaptation of signaling pathway adaptation of signaling pathway cellular cation homeostasis cellular divalent inorganic cation homeostasis trans-Golgi network transport vesicle sphingolipid biosynthetic process positive regulation of blood coagulation negative regulation of blood coagulation chondroitin sulfate metabolic process myofibril assembly polysaccharide binding negative regulation of ossification osteoclast differentiation growth cone site of polarized growth neutrophil chemotaxis synaptic vesicle membrane negative regulation of cyclic nucleotide metabolic process negative regulation of cyclic nucleotide biosynthetic process negative regulation of nucleotide biosynthetic process granulocyte differentiation regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation HOPS complex notochord development otic vesicle formation embryonic camera-type eye development developmental induction carboxylic acid binding neuromuscular junction ubiquitin protein ligase binding response to nutrient levels response to corticosteroid stimulus positive regulation of Ras GTPase activity positive regulation of Rho GTPase activity regulation of transporter activity response to peptidoglycan positive regulation of natural killer cell activation cell projection cytoplasm regulation of homeostatic process positive regulation of homeostatic process positive regulation of Rac GTPase activity activation of Ras GTPase activity activation of Rho GTPase activity activin receptor signaling pathway protein-lipid complex muscle cell proliferation regulation of mast cell activation response to vitamin activating transcription factor binding apolipoprotein binding diol metabolic process plasma lipoprotein particle very-low-density lipoprotein particle low-density lipoprotein particle high-density lipoprotein particle triglyceride-rich lipoprotein particle protein localization to chromosome RNA cap binding complex response to gonadotropin stimulus sodium channel complex chloride channel complex somatic stem cell maintenance establishment or maintenance of apical/basal cell polarity catenin import into nucleus regulation of catenin import into nucleus CD40 receptor complex regulation of meiosis chemoattractant activity T-helper 1 type immune response type 2 immune response T-helper cell differentiation acetylcholine binding interleukin-6 biosynthetic process peptide binding vasoconstriction cellular biogenic amine biosynthetic process thyroid hormone metabolic process dopamine metabolic process ear morphogenesis odontogenesis auditory receptor cell differentiation tyrosine phosphorylation of Stat3 protein regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat3 protein benzene-containing compound metabolic process retinoic acid metabolic process zymogen granule fibrinolysis eating behavior protein homodimerization activity neuropeptide binding amyloid precursor protein metabolic process amyloid precursor protein catabolic process costamere peptide biosynthetic process DNA methylation involved in gamete generation germ cell nucleus penile erection amino acid import L-amino acid import regulation of vascular permeability amine binding P granule dendritic shaft perikaryon sodium-independent organic anion transport regulation of ion transport positive regulation of ion transport leukocyte degranulation regulation of CD4-positive- alpha-beta T cell differentiation positive regulation of CD4-positive- alpha-beta T cell differentiation positive regulation of MAP kinase activity neuroprotection ADP binding positive regulation of GTPase activity keratinocyte proliferation regulation of anion transport early endosome to late endosome transport regulated secretory pathway regulation of bone resorption bioactive lipid receptor activity development of primary sexual characteristics cell-cell signaling involved in cell fate commitment apical part of cell establishment or maintenance of epithelial cell apical/basal polarity sarcomere organization gamma-catenin binding regulation of interleukin-6 biosynthetic process myoblast differentiation pole plasm mast cell activation negative regulation of fat cell differentiation regulation of keratinocyte differentiation regulation of T-helper cell differentiation regulation of myeloid cell differentiation negative regulation of myeloid cell differentiation regulation of osteoclast differentiation negative regulation of osteoclast differentiation positive regulation of osteoclast differentiation positive regulation of epidermis development negative regulation of glial cell differentiation positive regulation of epidermal growth factor receptor signaling pathway positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of heart contraction positive regulation of mitosis regulation of survival gene product expression positive regulation of exocytosis negative regulation of muscle contraction regulation of fatty acid oxidation membrane lipid biosynthetic process sphingoid biosynthetic process development of primary female sexual characteristics development of primary male sexual characteristics alpha-beta T cell proliferation negative regulation of alpha-beta T cell activation regulation of alpha-beta T cell proliferation positive regulation of alpha-beta T cell proliferation female sex differentiation male sex differentiation negative regulation of insulin secretion decidualization regulation of bone remodeling carboxylic acid transport carboxylic acid transmembrane transporter activity vascular endothelial growth factor receptor signaling pathway embryonic eye morphogenesis lymphocyte chemotaxis Rac GTPase binding retinoic acid receptor signaling pathway cell maturation positive regulation of behavior embryonic camera-type eye morphogenesis reproductive structure development organ formation negative regulation of smooth muscle cell proliferation astrocyte differentiation oligodendrocyte differentiation regulation of astrocyte differentiation regulation of oligodendrocyte differentiation pigment granule organization hair follicle maturation catecholamine secretion regulation of catecholamine secretion chondroitin sulfate proteoglycan metabolic process negative regulation of protein secretion negative regulation of cytokine secretion regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior positive regulation of synaptic transmission synapse organization positive regulation of coagulation positive chemotaxis regulation of chemotaxis positive regulation of chemotaxis positive regulation of positive chemotaxis induction of positive chemotaxis quaternary ammonium group binding negative regulation of secretion positive regulation of transport sequestering of metal ion positive regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol establishment of spindle localization prophase response to glucocorticoid stimulus response to mineralocorticoid stimulus response to corticosterone stimulus regulation of meiotic cell cycle elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 seco regulation of stress fiber assembly positive regulation of stress fiber assembly spindle localization positive regulation of nuclear division mitochondrial depolarization regulation of cardioblast differentiation negative regulation of protein kinase B signaling cascade membrane depolarization regulation of fibrinolysis sulfation regulation of calcium ion transport positive regulation of calcium ion transport catecholamine transport regulation of amine transport positive regulation of transmission of nerve impulse regulation of chromosome segregation cardiac muscle tissue growth regulation of cardiac muscle tissue growth regulation of cardiac muscle tissue development divalent inorganic cation homeostasis calcium ion homeostasis cation homeostasis response to hyperoxia cardiac muscle cell proliferation regulation of cardiac muscle cell proliferation mammary gland involution inner ear receptor cell development germ plasm trabecula formation endochondral bone morphogenesis response to growth hormone stimulus mammary gland morphogenesis branching involved in mammary gland duct morphogenesis mammary gland duct morphogenesis mammary gland epithelial cell differentiation labyrinthine layer morphogenesis mammary gland alveolus development positive regulation of protein tyrosine kinase activity establishment or maintenance of bipolar cell polarity mammary gland lobule development trabecula morphogenesis adenylyltransferase activity regulation of protein processing transepithelial transport response to interleukin-6 C2H2 zinc finger domain binding cellular response to acid cellular response to amino acid stimulus cellular response to interleukin-1 cellular response to organic nitrogen cellular response to amine stimulus cellular response to oxygen radical cellular response to superoxide genetic imprinting otic vesicle development otic vesicle morphogenesis blood coagulation- fibrin clot formation purine-containing compound transmembrane transport lymphocyte migration regulation of neutrophil chemotaxis regulation of cholesterol metabolic process regulation of release of cytochrome c from mitochondria positive regulation of release of cytochrome c from mitochondria negative regulation of peptide hormone secretion positive regulation of receptor activity regulation of CD4-positive- alpha-beta T cell activation positive regulation of CD4-positive- alpha-beta T cell activation sulfur amino acid biosynthetic process SNARE binding two-component sensor activity nuclear-transcribed mRNA poly(A) tail shortening cartilage condensation pseudouridine synthesis proteoglycan metabolic process sulfur compound metabolic process lipopolysaccharide binding cornified envelope oocyte maturation patterning of blood vessels heterophilic cell-cell adhesion urogenital system development endoderm formation immunological synapse negative regulation of cytokine production trophectodermal cell differentiation positive regulation of T cell mediated cytotoxicity negative regulation of endothelial cell proliferation positive regulation of cell-matrix adhesion negative regulation of cytokine-mediated signaling pathway regulation of systemic arterial blood pressure by hormone regulation of receptor internalization positive regulation of defense response to virus by host activation of immune response myeloid cell activation involved in immune response immune response to tumor cell antigen processing and presentation of peptide antigen via MHC class I regulation of immunoglobulin production regulation of B cell mediated immunity immune response-activating signal transduction immune response-regulating signaling pathway regulation of immunoglobulin mediated immune response regulation of systemic arterial blood pressure by renin-angiotensin ventricular cardiac muscle tissue development axoneme defense response to fungus serine-type endopeptidase activity calcium-dependent cysteine-type endopeptidase activity serine-type peptidase activity histone deacetylase activity protein histidine kinase activity triglyceride lipase activity growth factor binding death receptor binding transforming growth factor beta receptor binding neuropeptide hormone activity water transmembrane transporter activity nucleocytoplasmic transporter activity tropomyosin binding basal lamina autophagic vacuole Golgi lumen COPI vesicle coat COPI-coated vesicle nicotinic acetylcholine-gated receptor-channel complex carbohydrate metabolic process regulation of glycogen biosynthetic process aminoglycan metabolic process 2-oxoglutarate metabolic process nucleotide-excision repair- DNA gap filling DNA alkylation DNA methylation chromatin silencing chaperone-mediated protein complex assembly glycine metabolic process methionine metabolic process cellular modified amino acid metabolic process cellular aromatic compound metabolic process nitric oxide biosynthetic process exocytosis intra-Golgi vesicle-mediated transport tyrosine phosphorylation of STAT protein nitric oxide mediated signal transduction embryonic pattern specification neuromuscular junction development digestion visual perception pattern recognition receptor activity phosphoric diester hydrolase activity defense response to Gram-positive bacterium secondary active sulfate transmembrane transporter activity O-acyltransferase activity fucosyltransferase activity regulation of Notch signaling pathway glutamine family amino acid biosynthetic process methionine biosynthetic process purine base biosynthetic process nucleoside biosynthetic process detection of biotic stimulus photoreceptor activity pseudouridine synthase activity oocyte differentiation regulation of cell fate commitment negative regulation of endothelial cell migration positive regulation of cell-substrate adhesion positive regulation of glucose transport positive regulation of pathway-restricted SMAD protein phosphorylation regulation of receptor biosynthetic process cholesterol storage regulation of cholesterol storage macrophage cytokine production regulation of macrophage cytokine production regulation of glucan biosynthetic process regulation of muscle hypertrophy response to activity myotube differentiation sulfate transmembrane transporter activity water channel activity alcohol transmembrane transporter activity monocarboxylic acid transport bile acid and bile salt transport fatty acid transport long-chain fatty acid transport organic acid biosynthetic process positive regulation of glucose import C-acyltransferase activity gene silencing myosin II complex protein-hormone receptor activity oxidoreductase activity- acting on the CH-NH2 group of donors oxidoreductase activity- acting on the CH-NH2 group of donors- oxygen as acceptor oxidoreductase activity- acting on the CH-NH group of donors- NAD or NADP as acceptor transferase activity- transferring nitrogenous groups phosphotransferase activity- nitrogenous group as acceptor carbon-sulfur lyase activity intramolecular oxidoreductase activity- interconverting aldoses and ketoses intramolecular oxidoreductase activity- interconverting keto- and enol-groups intramolecular transferase activity ligase activity- forming carbon-sulfur bonds acid-thiol ligase activity transcription initiation factor activity syntaxin-1 binding fibroblast growth factor binding NAD-dependent histone deacetylase activity serine hydrolase activity peptidyl-cysteine modification protein-chromophore linkage deacetylase activity deaminase activity triglyceride biosynthetic process stem cell maintenance syntaxin binding cGMP-mediated signaling interleukin-1 binding neural tube patterning cerebral cortex cell migration forebrain cell migration telencephalon cell migration cellular process involved in reproduction in multicellular organism regulation of Wnt receptor signaling pathway proteoglycan biosynthetic process negative regulation of Wnt receptor signaling pathway protein kinase activator activity intestinal cholesterol absorption negative regulation of axon extension COPI coated vesicle membrane GTP-dependent protein binding positive regulation of cyclic nucleotide metabolic process positive regulation of cyclic nucleotide biosynthetic process positive regulation of nucleotide biosynthetic process positive regulation of cAMP metabolic process positive regulation of cAMP biosynthetic process positive regulation of B cell proliferation histone deacetylase activity (H3-K14 specific) organelle membrane positive regulation of microtubule polymerization or depolymerization regulation of microtubule polymerization positive regulation of microtubule polymerization chromatin DNA binding brush border membrane actin cytoskeleton reorganization killing of cells of other organism lipopolysaccharide-mediated signaling pathway filamentous actin NAD-dependent histone deacetylase activity (H3-K14 specific) positive regulation of protein binding histone deacetylase activity (H3-K9 specific) telomere maintenance via semi-conservative replication regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly icosanoid secretion intracellular lipid transport negative regulation of type I interferon production response to lipopolysaccharide response to progesterone stimulus interleukin-6 production tumor necrosis factor production regulation of interleukin-6 production regulation of tumor necrosis factor production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production receptor biosynthetic process regulation of polysaccharide metabolic process regulation of polysaccharide biosynthetic process regulation of organic acid transport positive regulation of mononuclear cell proliferation response to vitamin D protein deacetylase activity regulation of growth of symbiont in host negative regulation of growth of symbiont in host nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process purine ribonucleoside bisphosphate metabolic process plasma lipoprotein particle clearance histone deacetylase activity (H3-K16 specific) NAD-dependent protein deacetylase activity cardiac cell differentiation segmentation hippo signaling cascade CD4-positive- alpha-beta T cell activation regulation of growth regulation of gene expression- epigenetic regulation of fibroblast growth factor receptor signaling pathway positive regulation of activated T cell proliferation negative regulation of protein import into nucleus purine nucleoside biosynthetic process ribonucleoside biosynthetic process middle ear morphogenesis tyrosine phosphorylation of Stat5 protein regulation of tyrosine phosphorylation of STAT protein regulation of tyrosine phosphorylation of Stat5 protein positive regulation of tyrosine phosphorylation of Stat5 protein positive regulation of tyrosine phosphorylation of STAT protein tumor necrosis factor biosynthetic process regulation of tumor necrosis factor biosynthetic process specific granule regulation of cell fate specification cellular metabolic compound salvage purine-containing compound salvage anion binding apoptotic cell clearance response to exogenous dsRNA CD4-positive- alpha-beta T cell differentiation endothelial cell migration phosphatidylinositol 3-kinase binding negative regulation of multi-organism process regulation of symbiosis- encompassing mutualism through parasitism modification by symbiont of host morphology or physiology growth involved in symbiotic interaction growth of symbiont involved in interaction with host growth of symbiont in host modulation of growth of symbiont involved in interaction with host negative regulation of growth of symbiont involved in interaction with host lipid digestion sulfur compound biosynthetic process endoplasmic reticulum part axoneme part innate immune response response to copper ion regulation of isotype switching quinone cofactor biosynthetic process regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process regulation of epidermal cell differentiation negative regulation of neuron differentiation regulation of epidermis development positive regulation of glycogen biosynthetic process positive regulation of smoothened signaling pathway positive regulation of vasoconstriction negative regulation of nucleotide metabolic process positive regulation of nucleotide metabolic process regulation of activated T cell proliferation nucleobase biosynthetic process purine ribonucleoside biosynthetic process nitric oxide metabolic process carboxylic acid biosynthetic process neutral lipid biosynthetic process acylglycerol biosynthetic process glycerol ether biosynthetic process negative regulation of Ras protein signal transduction sphingolipid binding alpha-beta T cell activation alpha-beta T cell differentiation regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell activation regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell differentiation muscle cell homeostasis acid secretion microtubule polymerization regulation of lipid biosynthetic process NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) antigen processing and presentation of peptide antigen Golgi vesicle budding vesicle targeting- to- from or within Golgi Golgi transport vesicle coating COPI coating of Golgi vesicle oogenesis oocyte development negative regulation of muscle organ development negative regulation of developmental growth cardiac muscle tissue development skeletal muscle fiber development muscle fiber development stem cell differentiation stem cell development 3-phosphoadenosine 5-phosphosulfate metabolic process arachidonic acid secretion positive regulation of lymphocyte proliferation regulation of defense response to virus by host WW domain binding low-density lipoprotein particle receptor binding regulation of phagocytosis positive regulation of phagocytosis positive regulation of immune response activated T cell proliferation positive regulation of B cell activation endocrine process neuromuscular process sensory perception of light stimulus negative regulation of small GTPase mediated signal transduction smooth muscle cell differentiation regulation of muscle cell differentiation negative regulation of muscle cell differentiation regulation of smooth muscle cell differentiation regulation of striated muscle cell differentiation cytoplasmic sequestering of protein regulation of cytoskeleton organization 2 iron- 2 sulfur cluster binding glycolipid binding muscle cell development striated muscle cell development cardiac cell development cardiac muscle cell differentiation cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis cardiac muscle cell development nucleobase- nucleoside and nucleotide metabolic process maternal process involved in female pregnancy regulation of transcription initiation from RNA polymerase II promoter regulation of response to interferon-gamma regulation of interferon-gamma-mediated signaling pathway pathway-restricted SMAD protein phosphorylation regulation of pathway-restricted SMAD protein phosphorylation muscle tissue morphogenesis heart growth regulation of heart growth regulation of vesicle-mediated transport placenta blood vessel development cell differentiation involved in embryonic placenta development labyrinthine layer blood vessel development negative regulation of response to cytokine stimulus myeloid leukocyte cytokine production lipoprotein particle receptor binding negative regulation of ERK1 and ERK2 cascade response to fatty acid regulation of leukocyte proliferation positive regulation of leukocyte proliferation regulation of glycogen metabolic process positive regulation of glycogen metabolic process cellular response to growth factor stimulus anatomical structure maturation tumor necrosis factor superfamily cytokine production icosanoid transport DNA biosynthetic process modified amino acid binding protein activation cascade regulation of plasma lipoprotein particle levels regulation of transcription initiation- DNA-dependent regulatory region DNA binding regulatory region nucleic acid binding regulation of action potential cell fate specification ruffle neuron migration cytokine production regulation of cytokine production kidney development phospholipid-translocating ATPase activity amino acid transmembrane transporter activity phospholipid transporter activity cell cortex monosaccharide metabolic process glucose metabolic process organic acid metabolic process oxidation-reduction process glutathione metabolic process coenzyme metabolic process water-soluble vitamin metabolic process water transport cell-cell junction assembly JNK cascade skeletal muscle tissue development regulation of insulin secretion regulation of steroid biosynthetic process cell recognition signalosome coenzyme biosynthetic process amine metabolic process response to drug response to metal ion response to hexose stimulus response to glucose stimulus post-embryonic development axis specification dorsal/ventral pattern formation glial cell differentiation negative regulation of cell development regulation of mitochondrion organization promoter binding negative regulation of steroid biosynthetic process cellular component assembly positive regulation of peptidase activity regulation of neuron projection development regulation of gliogenesis dendrite development oxidoreductase activity- acting on single donors with incorporation of molecular oxygen peptidyl-serine phosphorylation regulation of steroid metabolic process regulation of vasoconstriction hexose metabolic process carboxylic acid metabolic process antigen processing and presentation PDZ domain binding positive regulation of Wnt receptor signaling pathway epithelial cell differentiation stress-activated protein kinase signaling cascade leading edge membrane regulation of defense response negative regulation of response to external stimulus activation of protein kinase activity ruffle membrane mononuclear cell proliferation regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation negative regulation of kinase activity response to monosaccharide stimulus response to interferon-gamma fluid transport gliogenesis cellular ketone metabolic process negative regulation of apoptosis negative regulation of programmed cell death apical junction assembly regulation of MAP kinase activity regulation of MAPKKK cascade positive regulation of MAPKKK cascade oxoacid metabolic process regulation of neuron apoptosis response to estrogen stimulus cellular amine metabolic process transcription regulatory region DNA binding cellular carbohydrate metabolic process positive regulation of interferon-gamma biosynthetic process intermediate filament-based process intermediate filament cytoskeleton organization positive regulation of neuron differentiation regulation of glial cell differentiation regulation of synaptic plasticity synaptic vesicle transport branching morphogenesis of a tube multicellular organismal homeostasis negative regulation of epithelial cell proliferation interleukin-1 beta secretion regulation of interleukin-1 secretion regulation of interleukin-1 beta secretion positive regulation of interleukin-1 secretion positive regulation of interleukin-1 beta secretion negative regulation of neurogenesis positive regulation of neurogenesis negative regulation of axonogenesis GTPase binding positive regulation of secretion regulation of cell division positive regulation of hydrolase activity neuron apoptosis detection of stimulus regulation of calcium ion transport via voltage-gated calcium channel activity lipid homeostasis retina development in camera-type eye bone morphogenesis skeletal muscle organ development negative regulation of cell death morphogenesis of a branching epithelium mammary gland epithelium development neural precursor cell proliferation ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade calcium ion transmembrane transport neuron death positive regulation of protein serine/threonine kinase activity renal system development regulation of response to stress negative regulation of canonical Wnt receptor signaling pathway very long-chain fatty acid metabolic process activation of MAPKK activity heterotrimeric G-protein complex polysaccharide biosynthetic process lytic vacuole neurotransmitter biosynthetic process regulation of cell growth G-protein-coupled receptor binding long-chain fatty acid metabolic process leukocyte homeostasis embryonic placenta development cell killing photoreceptor inner segment lens development in camera-type eye response to molecule of bacterial origin lymphocyte homeostasis immune response-activating cell surface receptor signaling pathway platelet degranulation negative regulation of immune system process negative regulation of leukocyte activation positive regulation of immune effector process regulation of production of molecular mediator of immune response regulation of leukocyte mediated immunity renal system process vascular process in circulatory system actin filament depolymerization endopeptidase activity lysosome metallopeptidase activity cell adhesion molecule binding phosphatidylinositol phospholipase C activity glutathione peroxidase activity phospholipase activity calmodulin-dependent protein kinase activity protein kinase C activity tubulin-tyrosine ligase activity enzyme inhibitor activity cyclin-dependent protein kinase inhibitor activity serine-type endopeptidase inhibitor activity scavenger receptor activity transmembrane receptor protein serine/threonine kinase signaling pathway microtubule tight junction glycogen metabolic process glycogen catabolic process cellular glucan metabolic process protein complex assembly negative regulation of protein kinase activity phospholipid metabolic process androgen biosynthetic process vitamin metabolic process xenobiotic metabolic process phagocytosis- engulfment anti-apoptosis smooth muscle contraction regulation of smooth muscle contraction striated muscle contraction response to mechanical stimulus epidermal growth factor receptor signaling pathway activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway salivary gland development female pregnancy steroid metabolic process androgen metabolic process galactosyltransferase activity ATPase activity- coupled to transmembrane movement of ions- phosphorylative mechanism protein kinase regulator activity activation of pro-apoptotic gene products glucan catabolic process amine biosynthetic process phospholipid catabolic process response to xenobiotic stimulus detection of chemical stimulus internal side of plasma membrane epidermal cell differentiation basal plasma membrane regulation of autophagy negative regulation of phosphorus metabolic process regulation of lipid storage positive regulation of lipid storage organic cation transmembrane transporter activity symporter activity microtubule cytoskeleton phospholipid transport lipase activity lateral plasma membrane cyclin-dependent protein kinase regulator activity transferase activity- transferring glycosyl groups peptidyl-serine modification kinase regulator activity sensory perception of pain extrinsic to plasma membrane extrinsic to membrane lipid storage spinal cord patterning spinal cord dorsal/ventral patterning cranial nerve development nerve development Z disc regulation of endocytosis glycosaminoglycan metabolic process keratinocyte differentiation protein serine/threonine kinase inhibitor activity negative regulation of cell growth T-tubule BMP signaling pathway endocytic vesicle membrane ovulation regulation of actin filament depolymerization negative regulation of actin filament depolymerization negative regulation of actin filament polymerization cortical cytoskeleton organization cortical actin cytoskeleton organization regulation of B cell proliferation negative regulation of B cell proliferation actomyosin structure organization platelet alpha granule platelet alpha granule lumen extrinsic to internal side of plasma membrane keratinization receptor internalization I band vesicle lumen regulation of intracellular transport positive regulation of ATPase activity monocarboxylic acid metabolic process regulation of protein localization regulation of mononuclear cell proliferation regulation of intracellular protein transport tumor necrosis factor-mediated signaling pathway regulation of tissue remodeling response to fluid shear stress response to tumor necrosis factor cellular hormone metabolic process positive regulation of transmembrane transport secretory granule lumen response to nicotine regulation of tube size T cell proliferation B cell proliferation regulation of T cell proliferation neurotransmitter metabolic process regulation of protein import into nucleus positive regulation of protein import into nucleus negative regulation of phosphorylation vitamin D metabolic process hormone biosynthetic process negative regulation of catalytic activity receptor metabolic process negative regulation of ion transport negative regulation of MAP kinase activity inositol phosphate metabolic process glucan metabolic process cellular polysaccharide catabolic process cellular lipid metabolic process cellular polysaccharide metabolic process basal part of cell positive regulation of cell adhesion negative regulation of cell size negative regulation of lipid metabolic process negative regulation of growth negative regulation of phosphate metabolic process regulation of JNK cascade lymphocyte proliferation regulation of nucleocytoplasmic transport regulation of neurotransmitter secretion fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation regulation of long-term neuronal synaptic plasticity rhythmic process developmental cell growth eye morphogenesis smooth muscle cell proliferation regulation of smooth muscle cell proliferation axon extension tissue remodeling dendrite morphogenesis regulation of lymphocyte proliferation positive regulation of inflammatory response regulation of dendrite development regulation of antigen receptor-mediated signaling pathway regulation of T cell receptor signaling pathway regulation of B cell activation negative regulation of cell activation negative regulation of T cell activation regulation of blood vessel size detection of light stimulus involved in visual perception detection of light stimulus involved in sensory perception regulation of lipid catabolic process positive regulation of lipid catabolic process regulation of protein transport negative regulation of protein transport maintenance of location negative regulation of lymphocyte activation protein oligomerization negative regulation of transferase activity regulation of neurotransmitter transport bacterial cell surface binding actin filament capping regulation of sensory perception of pain regulation of sensory perception regulation of endopeptidase activity carboxylic ester hydrolase activity cytoplasmic membrane-bounded vesicle lumen interferon-gamma-mediated signaling pathway mesenchyme development regulation of morphogenesis of a branching structure occluding junction regulation of establishment of protein localization regulation of lymphocyte apoptosis protein complex biogenesis protein kinase C signaling cascade growth factor receptor binding cellular response to molecule of bacterial origin cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to tumor necrosis factor cellular response to xenobiotic stimulus cellular response to external stimulus negative regulation of protein serine/threonine kinase activity positive regulation of establishment of protein localization in plasma membrane regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of muscle system process regulation of leukocyte apoptosis regulation of DNA recombination mannosyltransferase activity transition metal ion transport autophagic vacuole assembly tRNA binding fatty-acyl-CoA binding chromosome segregation chromosome organization mitotic sister chromatid segregation cell cycle checkpoint DNA replication checkpoint DNA damage checkpoint regulation of cyclin-dependent protein kinase activity G1 phase of mitotic cell cycle G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle S phase of mitotic cell cycle G2/M transition of mitotic cell cycle M phase of mitotic cell cycle sulfur amino acid metabolic process histone deacetylase complex ubiquitin ligase complex nuclear ubiquitin ligase complex protein phosphatase type 2A complex exosome (RNase complex) cytosolic large ribosomal subunit nuclear-transcribed mRNA catabolic process- nonsense-mediated decay protein ubiquitination involved in ubiquitin-dependent protein catabolic process M/G1 transition of mitotic cell cycle proton-transporting two-sector ATPase complex microtubule cytoskeleton organization nuclear chromosome condensed nuclear chromosome condensed chromosome mitotic prometaphase pericentriolar material spliceosome assembly proton-transporting ATPase activity- rotational mechanism GTPase activity mitochondrial fission mitotic cell cycle M phase nuclear division nuclear-transcribed mRNA catabolic process- deadenylation-dependent decay nuclear-transcribed mRNA catabolic process- exonucleolytic integral to membrane of membrane fraction response to reactive oxygen species organellar small ribosomal subunit spliceosomal snRNP assembly DNA-directed RNA polymerase complex telomere maintenance via recombination telomere maintenance double-strand break repair via homologous recombination recombinational repair non-recombinational repair DNA catabolic process- endonucleolytic chromosome- centromeric region kinetochore condensed chromosome kinetochore condensed chromosome- centromeric region condensed nuclear chromosome- centromeric region chromosome- telomeric region telomere cap complex nuclear telomere cap complex nuclear chromosome- telomeric region chromatin nucleosome nuclear chromatin heterochromatin synaptonemal complex sex chromosome sister chromatid segregation cytokinesis spindle pole cytoplasmic mRNA processing body condensed chromosome outer kinetochore nuclear-transcribed mRNA catabolic process sequence-specific DNA binding RNA polymerase II transcription factor activity cysteine-type endopeptidase activity RNA methylation prostaglandin biosynthetic process beta-amyloid binding vasculogenesis microtubule bundle formation nucleotide receptor activity- G-protein coupled purinergic nucleotide receptor activity metanephros development ameboidal cell migration acrosomal vesicle gastrulation with mouth forming second lipid kinase activity sex chromatin photoreceptor outer segment eye photoreceptor cell differentiation neural crest cell migration somitogenesis blastocyst development blastocyst formation release of cytochrome c from mitochondria neural tube formation neural tube closure receptor recycling nucleoside binding liver development leukocyte mediated cytotoxicity regulation of leukocyte mediated cytotoxicity positive regulation of leukocyte mediated cytotoxicity T cell mediated cytotoxicity regulation of T cell mediated cytotoxicity endothelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of cell-matrix adhesion negative regulation of cell-matrix adhesion synaptic transmission- dopaminergic retinoic acid binding blood vessel remodeling protease binding regulation of the force of heart contraction regulation of heart rate p53 binding epithelial cell development somatic diversification of immune receptors somatic recombination of immunoglobulin genes involved in immune response somatic diversification of immunoglobulins involved in immune response activation of innate immune response pattern recognition receptor signaling pathway toll-like receptor signaling pathway natural killer cell mediated immunity hemopoietic progenitor cell differentiation adaptive immune response cell activation involved in immune response lymphocyte activation involved in immune response B cell activation involved in immune response response to tumor cell leukocyte activation involved in immune response cytokine production involved in immune response immunoglobulin production immunoglobulin production involved in immunoglobulin mediated immune response inflammatory response to antigenic stimulus production of molecular mediator of immune response leukocyte mediated immunity lymphocyte mediated immunity humoral immune response mediated by circulating immunoglobulin T cell mediated immunity adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli production of molecular mediator involved in inflammatory response somatic diversification of immune receptors via germline recombination within a single locus regulation of leukocyte chemotaxis negative regulation of immune effector process positive regulation of production of molecular mediator of immune response positive regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity positive regulation of lymphocyte mediated immunity regulation of T cell mediated immunity positive regulation of T cell mediated immunity regulation of natural killer cell mediated immunity positive regulation of natural killer cell mediated immunity regulation of cytokine production involved in immune response positive regulation of cytokine production involved in immune response MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway innate immune response-activating signal transduction positive regulation of myeloid leukocyte differentiation positive regulation of peptide secretion regulation of adaptive immune response positive regulation of adaptive immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from positive regulation of adaptive immune response based on somatic recombination of immune receptors b regulation of inflammatory response to antigenic stimulus skeletal muscle contraction respiratory system process regulation of systemic arterial blood pressure mediated by a chemical signal regulation of systemic arterial blood pressure DNA helicase activity chromatin binding double-stranded DNA binding specific RNA polymerase II transcription factor activity sequence-specific enhancer binding RNA polymerase II transcription factor activity RNA polymerase III transcription factor activity transcription elongation regulator activity transcription coactivator activity transcription corepressor activity RNA binding RNA helicase activity double-stranded RNA binding mRNA 3-UTR binding ribonucleoprotein complex small nuclear ribonucleoprotein complex translation initiation factor activity translation elongation factor activity regulation of cell cycle chromatin assembly or disassembly nucleosome assembly nucleosome organization histone binding histone exchange chaperone binding response to unfolded protein protein refolding microtubule motor activity regulation of actin filament length acute-phase response complement activation MHC class I protein complex antigen binding DNA-directed DNA polymerase activity DNA-directed RNA polymerase activity DNA-(apurinic or apyrimidinic site) lyase activity hydrogen ion transporting ATP synthase activity- rotational mechanism NADH dehydrogenase activity ATP-dependent DNA helicase activity ATP-dependent RNA helicase activity cation-transporting ATPase activity ATPase activity- coupled to transmembrane movement of substances nucleoside-triphosphatase activity carboxylesterase activity cytochrome-c oxidase activity aminopeptidase activity metalloexopeptidase activity carboxypeptidase activity metallocarboxypeptidase activity aspartic-type endopeptidase activity mitochondrion threonine-type endopeptidase activity peptidase activity histone acetyltransferase activity inositol or phosphatidylinositol kinase activity inositol or phosphatidylinositol phosphatase activity lysine N-acetyltransferase activity nuclease activity endonuclease activity endodeoxyribonuclease activity endoribonuclease activity exonuclease activity exoribonuclease activity deoxyribonuclease activity ribonuclease activity peroxidase activity lysophospholipase activity phospholipase A2 activity phospholipase C activity prenyltransferase activity cyclin-dependent protein kinase activity receptor signaling protein serine/threonine kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity protein serine/threonine/tyrosine kinase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein phosphatase inhibitor activity cysteine-type endopeptidase inhibitor activity signal sequence binding peroxisomal membrane SH3/SH2 adaptor activity protein localization protein kinase C binding Rab GTPase activator activity Ras GTPase activator activity tumor necrosis factor receptor binding structural constituent of eye lens calcium activated cation channel activity calcium channel regulator activity voltage-gated chloride channel activity organic acid:sodium symporter activity L-glutamate transmembrane transporter activity lipid transporter activity glucose transmembrane transporter activity zinc ion transmembrane transporter activity vacuole organization vesicle fusion vesicle targeting SNAP receptor activity retinoid binding fatty acid binding copper ion binding collagen binding insulin-like growth factor binding macrolide binding FK506 binding mannose binding hyaluronic acid binding calcium-dependent phospholipid binding 1-phosphatidylinositol binding nuclear inner membrane nuclear outer membrane nuclear pore Ran GTPase binding nucleoplasm replication fork DNA-directed RNA polymerase II- core complex transcription factor TFIID complex anaphase-promoting complex spliceosomal complex U12-type spliceosomal complex chromosome nuclear heterochromatin mitochondrial respiratory chain mitochondrial respiratory chain complex I mitochondrial proton-transporting ATP synthase complex proton-transporting ATP synthase complex- coupling factor F(o) mitochondrial small ribosomal subunit endosome late endosome multivesicular body integral to peroxisomal membrane protein targeting to peroxisome peroxisomal part peroxisomal matrix endoplasmic reticulum lumen rough endoplasmic reticulum ER-Golgi intermediate compartment Golgi-associated vesicle ER to Golgi transport vesicle cis-Golgi network transport vesicle transport vesicle membrane secretory granule membrane centrosome centriole microtubule organizing center spindle proteasome core complex polysome mRNA cleavage factor complex eukaryotic translation initiation factor 3 complex microtubule associated complex spindle microtubule cytoplasmic microtubule actin filament brush border AP-type membrane coat adaptor complex gap junction connexon complex microtubule basal body phosphatidylinositol 3-kinase complex glycogen biosynthetic process ethanol metabolic process ethanol oxidation cellular aldehyde metabolic process acetyl-CoA metabolic process acetyl-CoA biosynthetic process acetyl-CoA biosynthetic process from pyruvate pyruvate metabolic process pentose-phosphate shunt tricarboxylic acid cycle oxaloacetate metabolic process regulation of glycolysis respiratory electron transport chain oxidative phosphorylation purine base metabolic process purine nucleoside metabolic process purine nucleotide catabolic process ATP catabolic process pyrimidine base metabolic process DNA-dependent DNA replication DNA ligation DNA-dependent DNA replication initiation DNA strand elongation involved in DNA replication RNA-dependent DNA replication regulation of DNA repair transcription-coupled nucleotide-excision repair double-strand break repair double-strand break repair via nonhomologous end joining DNA modification DNA fragmentation involved in apoptotic nuclear change DNA recombination mitotic recombination DNA packaging chromatin organization DNA replication-independent nucleosome assembly chromatin remodeling transcription initiation- DNA-dependent transcription termination- DNA-dependent transcription elongation- DNA-dependent transcription from RNA polymerase I promoter transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter termination of RNA polymerase II transcription mRNA capping mRNA polyadenylation mRNA cleavage transcription from RNA polymerase III promoter transcription elongation from RNA polymerase III promoter termination of RNA polymerase III transcription RNA processing tRNA modification RNA catabolic process mRNA catabolic process RNA localization RNA export from nucleus mRNA export from nucleus de novo protein folding protein dephosphorylation protein deacetylation protein methylation protein demethylation protein glycosylation protein N-linked glycosylation dolichol-linked oligosaccharide biosynthetic process protein O-linked glycosylation protein lipidation C-terminal protein lipidation GPI anchor metabolic process GPI anchor biosynthetic process membrane protein ectodomain proteolysis glycoprotein catabolic process peptide metabolic process cellular amino acid metabolic process regulation of cellular amino acid metabolic process glutamine metabolic process tryptophan metabolic process tryptophan catabolic process indolalkylamine metabolic process polyamine metabolic process NLS-bearing substrate import into nucleus protein targeting to membrane cotranslational protein targeting to membrane protein targeting to mitochondrion fatty acid beta-oxidation unsaturated fatty acid biosynthetic process acyl-CoA metabolic process membrane lipid metabolic process phosphatidylinositol biosynthetic process glycolipid metabolic process sphingolipid metabolic process ceramide metabolic process glycosphingolipid metabolic process icosanoid metabolic process leukotriene metabolic process prostanoid metabolic process prostaglandin metabolic process cholesterol biosynthetic process one-carbon metabolic process oxidoreduction coenzyme metabolic process NADP metabolic process NADPH regeneration ATP biosynthetic process folic acid-containing compound metabolic process porphyrin metabolic process reactive oxygen species metabolic process superoxide metabolic process hydrogen transport chloride transport copper ion transport iron ion transport zinc ion transport L-glutamate transport cellular iron ion homeostasis cellular zinc ion homeostasis intracellular protein transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport- Golgi to ER post-Golgi vesicle-mediated transport receptor-mediated endocytosis membrane budding vesicle coating vesicle docking involved in exocytosis autophagy activation of caspase activity cellular membrane fusion complement activation- alternative pathway complement activation- classical pathway response to DNA damage stimulus DNA damage response- signal transduction by p53 class mediator resulting in cell cycle arrest DNA damage response- signal transduction by p53 class mediator resulting in transcription of p21 cla ER overload response ER-nucleus signaling pathway nucleus organization telomeric DNA binding telomere maintenance via telomerase mitochondrion organization mitochondrial membrane organization plasma membrane organization microtubule depolymerization negative regulation of microtubule depolymerization Golgi organization peroxisome organization endosome organization vacuolar transport lysosome organization lysosomal transport cell cycle cell cycle arrest spindle organization mitotic spindle organization sister chromatid cohesion mitosis mitotic chromosome condensation mitotic metaphase plate congression regulation of mitosis mitotic metaphase/anaphase transition mitotic cell cycle checkpoint mitotic cell cycle spindle assembly checkpoint centrosome cycle establishment of cell polarity meiosis meiosis I reciprocal meiotic recombination male meiosis leukocyte cell-cell adhesion establishment or maintenance of cell polarity SMAD protein import into nucleus Notch signaling pathway I-kappaB kinase/NF-kappaB cascade I-kappaB phosphorylation ensheathment of neurons germ cell development spermatid development binding of sperm to zona pellucida neuroblast proliferation peripheral nervous system development embryo implantation cell aging natural killer cell mediated cytotoxicity respiratory gaseous exchange body fluid secretion lactation phototransduction phototransduction- visible light detection of chemical stimulus involved in sensory perception of taste learning memory mating copulation rhythmic behavior circadian rhythm chemokine activity microtubule binding protein C-terminus binding transcription elongation factor complex monocarboxylic acid transmembrane transporter activity tRNA processing lipoprotein particle binding Toll signaling pathway regulation of actin polymerization or depolymerization N-acetyltransferase activity DNA-dependent ATPase activity translation factor activity- nucleic acid binding protein tyrosine/serine/threonine phosphatase activity drug binding actin polymerization or depolymerization negative regulation of DNA replication viral genome replication methyltransferase activity N-methyltransferase activity RNA methyltransferase activity tRNA methyltransferase activity RNA-dependent ATPase activity ion channel inhibitor activity protein alkylation protein dealkylation cytolysis defense response to Gram-negative bacterium oligosaccharyltransferase complex nucleotidase activity sulfate transport protein methyltransferase activity cohesin complex protein serine/threonine phosphatase complex isoprenoid biosynthetic process DNA bending activity voltage-gated anion channel activity protein transmembrane transporter activity endosome to lysosome transport histone mRNA metabolic process RNA polymerase II carboxy-terminal domain kinase activity axon ensheathment acetylglucosaminyltransferase activity 3-5 exonuclease activity negative regulation of coagulation heterogeneous nuclear ribonucleoprotein complex ATPase activity protein phosphatase type 2A regulator activity induction of apoptosis by intracellular signals DNA damage response- signal transduction resulting in induction of apoptosis activation of caspase activity by cytochrome c apoptotic mitochondrial changes carbohydrate transport hexose transport positive regulation of vasodilation positive regulation of smooth muscle contraction actin filament polymerization cellular amino acid biosynthetic process S-adenosylmethionine-dependent methyltransferase activity catabolic process macromolecule catabolic process fatty acid catabolic process cellular amino acid catabolic process glutamine family amino acid metabolic process glutamine family amino acid catabolic process aspartate family amino acid metabolic process aspartate family amino acid biosynthetic process serine family amino acid metabolic process aromatic amino acid family metabolic process aromatic amino acid family catabolic process branched chain family amino acid metabolic process branched chain family amino acid catabolic process coenzyme catabolic process nucleobase metabolic process purine nucleoside monophosphate metabolic process purine nucleoside monophosphate biosynthetic process nucleoside diphosphate metabolic process purine nucleoside triphosphate metabolic process purine ribonucleotide metabolic process ribonucleoside monophosphate biosynthetic process ribonucleoside monophosphate metabolic process nucleoside catabolic process purine ribonucleoside monophosphate metabolic process purine ribonucleoside monophosphate biosynthetic process ribonucleoside triphosphate metabolic process purine ribonucleoside triphosphate metabolic process nucleotide-sugar metabolic process glucan biosynthetic process ribonucleotide metabolic process response to temperature stimulus cellular response to starvation nucleoid rRNA transcription amine catabolic process oligosaccharide metabolic process oligosaccharide biosynthetic process viral reproduction response to heat response to cold response to UV response to light stimulus RNA modification RNA capping detection of abiotic stimulus detection of light stimulus detection of visible light UV protection cell-cell recognition response to zinc ion response to X-ray body morphogenesis FMN binding response to ionizing radiation response to lithium ion NADH dehydrogenase complex assembly multicellular organismal aging response to gamma radiation regulation of acetyl-CoA biosynthetic process from pyruvate misfolded protein binding regulation of cell cycle process vascular endothelial growth factor production regulation of vascular endothelial growth factor production positive regulation vascular endothelial growth factor production regulation of endothelial cell migration positive regulation of endothelial cell migration positive regulation of organelle organization negative regulation of organelle organization negative regulation of cellular carbohydrate metabolic process negative regulation of intracellular protein kinase cascade macrophage derived foam cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation regulation of cell-substrate adhesion negative regulation of cell-substrate adhesion regulation of glucose transport telomere maintenance via telomere lengthening regulation of phosphatase activity cellular component assembly involved in morphogenesis negative regulation of cell cycle process microtubule-based transport negative regulation of neuron projection development ER to Golgi transport vesicle membrane positive regulation of gliogenesis neural crest cell development neural crest cell differentiation Schwann cell differentiation phosphatidylinositol 3-kinase cascade regulation of phosphatidylinositol 3-kinase cascade positive regulation of phosphatidylinositol 3-kinase cascade response to isoquinoline alkaloid muscle cell migration muscle hypertrophy smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of smooth muscle cell migration heme-copper terminal oxidase activity Cajal body protein transport oxygen binding retinal binding DNA integration calcium ion transmembrane transporter activity inorganic anion transmembrane transporter activity bile acid transmembrane transporter activity carbohydrate transmembrane transporter activity monosaccharide transmembrane transporter activity hexose transmembrane transporter activity acidic amino acid transmembrane transporter activity peptide transporter activity vitamin transporter activity sugar transmembrane transporter activity calcium-activated potassium channel activity pore complex solute:cation symporter activity solute:hydrogen symporter activity anion:cation symporter activity primary active transmembrane transporter activity P-P-bond-hydrolysis-driven transmembrane transporter activity P-P-bond-hydrolysis-driven protein transmembrane transporter activity potassium channel regulator activity tubulin binding organic cation transport quaternary ammonium group transport inorganic anion transport organic anion transport monosaccharide transport glucose transport acidic amino acid transport L-amino acid transport betaine transport vitamin transport carnitine transport sterol transport mannosidase activity glucosidase activity hexosaminidase activity nucleobase- nucleoside- nucleotide and nucleic acid transport nucleobase- nucleoside- nucleotide and nucleic acid transmembrane transporter activity proton transport energy coupled proton transport- down electrochemical gradient ATP synthesis coupled proton transport energy coupled proton transport- against electrochemical gradient ATP hydrolysis coupled proton transport vesicle organization organic acid catabolic process immunoglobulin mediated immune response mRNA metabolic process snRNA metabolic process sterol biosynthetic process snRNA processing endosome transport inclusion body aggresome macroautophagy channel regulator activity channel inhibitor activity general RNA polymerase II transcription factor activity preassembly of GPI anchor in ER membrane lysine N-methyltransferase activity protein-lysine N-methyltransferase activity CoA hydrolase activity acyl-CoA thioesterase activity negative regulation of G-protein coupled receptor protein signaling pathway dephosphorylation calcium-independent cell-cell adhesion nuclear matrix acetyltransferase activity palmitoyltransferase activity N-acyltransferase activity somatic cell DNA recombination somatic diversification of immunoglobulins somatic recombination of immunoglobulin gene segments RNA polymerase II transcription mediator activity pyrophosphatase activity peptidase activator activity nucleotide receptor activity SWI/SNF complex negative regulation of angiogenesis sarcoplasm sarcoplasmic reticulum protein import into peroxisome matrix specific transcriptional repressor activity histone methylation histone ubiquitination histone deacetylation histone deubiquitination NuRD complex chromatin remodeling complex DNA-directed RNA polymerase II- holoenzyme mediator complex amino acid binding PML body oxidoreductase activity- acting on the aldehyde or oxo group of donors- NAD or NADP as acceptor oxidoreductase activity- acting on the aldehyde or oxo group of donors oxidoreductase activity- acting on the CH-CH group of donors oxidoreductase activity- acting on the CH-CH group of donors- NAD or NADP as acceptor oxidoreductase activity- acting on the CH-NH group of donors oxidoreductase activity- acting on NADH or NADPH- quinone or similar compound as acceptor oxidoreductase activity- acting on a heme group of donors oxidoreductase activity- acting on a heme group of donors- oxygen as acceptor oxidoreductase activity- acting on peroxide as acceptor oxidoreductase activity- acting on CH or CH2 groups transferase activity- transferring one-carbon groups nucleotidyltransferase activity phosphotransferase activity- for other substituted phosphate groups hydrolase activity- acting on ester bonds exonuclease activity- active with either ribo- or deoxyribonucleic acids and producing 5-phosphomono hydrolase activity- hydrolyzing N-glycosyl compounds hydrolase activity- acting on carbon-nitrogen (but not peptide) bonds- in cyclic amidines hydrolase activity- acting on acid anhydrides hydrolase activity- acting on acid anhydrides- in phosphorus-containing anhydrides hydrolase activity- acting on acid anhydrides- catalyzing transmembrane movement of substances carbon-carbon lyase activity carboxy-lyase activity carbon-oxygen lyase activity hydro-lyase activity racemase and epimerase activity endoribonuclease activity- producing 5-phosphomonoesters endonuclease activity- active with either ribo- or deoxyribonucleic acids and producing 5-phosphomon exoribonuclease activity- producing 5-phosphomonoesters ligand-dependent nuclear receptor binding thyroid hormone receptor binding protein sumoylation cell wall macromolecule catabolic process regulation of transforming growth factor beta receptor signaling pathway Ras GTPase binding MAP kinase tyrosine/serine/threonine phosphatase activity myosin binding TBP-class protein binding protein stabilization positive regulation of hormone secretion Rho GTPase binding transcriptional repressor complex response to antibiotic drug metabolic process stem cell division peptidyl-glutamic acid carboxylation histone-lysine N-methyltransferase activity peptidyl-threonine phosphorylation peptidyl-asparagine modification peptidyl-glutamic acid modification peptidyl-proline modification peptidyl-threonine modification protein carboxylation protein N-linked glycosylation via asparagine C-terminal protein amino acid modification GDP binding virus-host interaction initiation of viral infection phosphatase regulator activity kinase activator activity phosphatase inhibitor activity regulation of action potential in neuron pyridine nucleotide metabolic process leukotriene biosynthetic process glycolipid catabolic process fatty acid oxidation triglyceride catabolic process aromatic compound biosynthetic process aromatic compound catabolic process urea metabolic process NAD metabolic process B cell mediated immunity isoprenoid binding retinol binding rRNA binding protein phosphatase regulator activity phosphatase binding protein phosphatase binding phosphatidylinositol-mediated signaling inositol lipid-mediated signaling cerebellar Purkinje cell layer development cerebellar cortex development glial cell development cell proliferation in forebrain cerebral cortex development cell cycle process cell cycle phase membrane docking regulation of cell-cell adhesion positive regulation of cell-cell adhesion circadian sleep/wake cycle process digestive system process DNA strand elongation proteasome accessory complex wide pore channel activity macromolecule transmembrane transporter activity cellular monovalent inorganic cation homeostasis extracellular matrix binding cell projection assembly lamellipodium assembly microspike assembly regulation of mitotic metaphase/anaphase transition natural killer cell activation membrane coat clathrin coat vesicle coat clathrin vesicle coat clathrin adaptor complex sphingolipid catabolic process protein catabolic process low-density lipoprotein particle binding pyridoxal phosphate binding regulation of DNA-dependent DNA replication initiation regulation of blood coagulation collagen fibril organization erythrocyte differentiation monocyte differentiation lipid modification chromosome condensation apoptotic nuclear change bone mineralization dynein complex cholesterol transport positive regulation of cell growth melanocyte differentiation DNA damage response- signal transduction by p53 class mediator estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity symbiosis- encompassing mutualism through parasitism sleep ER-associated protein catabolic process midbody regulation of bone mineralization positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of BMP signaling pathway regulation of axon extension steroid hormone receptor signaling pathway androgen receptor signaling pathway intracellular receptor mediated signaling pathway receptor regulator activity collagen catabolic process leukocyte chemotaxis regulation of cellular pH regulation of coenzyme metabolic process Golgi-associated vesicle membrane preribosome cytoskeleton-dependent intracellular transport regulation of actin filament polymerization positive regulation of actin filament polymerization cortical actin cytoskeleton rough endoplasmic reticulum membrane RNA polymerase complex STAGA complex NADH dehydrogenase complex endoplasmic reticulum unfolded protein response microtubule organizing center organization gene silencing by RNA chromatin remodeling at centromere Nup107-160 complex neuron projection regeneration microtubule polymerization or depolymerization regulation of microtubule polymerization or depolymerization negative regulation of microtubule polymerization or depolymerization regulation of microtubule depolymerization cytoplasmic microtubule organization RNA 3-end processing mRNA 3-end processing anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process intrinsic to peroxisomal membrane lamellipodium membrane small GTPase binding membrane protein intracellular domain proteolysis negative regulation of cellular catabolic process positive regulation of cellular catabolic process negative regulation of protein complex assembly positive regulation of protein complex assembly regulation of cell killing positive regulation of cell killing negative regulation of cell projection organization negative regulation of defense response N-terminal protein amino acid modification regulation of protein ubiquitination negative regulation of protein ubiquitination positive regulation of protein ubiquitination positive regulation of protein modification process cullin-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex chromatin assembly nonmotile primary cilium motile cilium PcG protein complex DNA integrity checkpoint mitotic cell cycle G1/S transition DNA damage checkpoint G2/M transition DNA damage checkpoint mitotic cell cycle G1/S transition checkpoint G2/M transition checkpoint spindle checkpoint zymogen activation positive regulation of neurological system process regulation of protein stability cellular response to nutrient levels cellular response to nutrient G-protein beta/gamma-subunit complex binding late endosome membrane microbody membrane microbody lumen TOR signaling cascade regulation of protein autophosphorylation positive regulation of protein autophosphorylation nuclear membrane organelle envelope envelope organelle subcompartment Golgi cisterna positive regulation of insulin secretion integrator complex negative regulation of NF-kappaB transcription factor activity cell division site cleavage furrow cell division site part telomere organization regulation of telomere maintenance regulation of synaptic transmission- dopaminergic methylation positive regulation of cellular protein metabolic process regulation of protein polymerization negative regulation of protein polymerization positive regulation of protein polymerization negative regulation of DNA-dependent DNA replication initiation regulation of Rab GTPase activity regulation of Rho GTPase activity regulation of lipid transport negative regulation of lipid transport positive regulation of intracellular transport photoreceptor connecting cilium DNA geometric change negative regulation of transporter activity negative regulation of ion transmembrane transporter activity positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of Rab protein signal transduction maintenance of protein location in cell DNA duplex unwinding Golgi cisterna membrane interferon-gamma production interleukin-1 beta production interleukin-1 production interleukin-10 production interleukin-12 production interleukin-17 production interleukin-2 production interleukin-8 production regulation of interferon-gamma production regulation of interleukin-1 beta production regulation of interleukin-1 production regulation of interleukin-10 production regulation of interleukin-12 production regulation of interleukin-17 production regulation of interleukin-2 production regulation of interleukin-8 production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of interleukin-8 production regulation of monooxygenase activity negative regulation of monooxygenase activity positive regulation of monooxygenase activity regulation of transcription elongation- DNA-dependent tumor necrosis factor receptor superfamily binding regulation of natural killer cell activation negative regulation of homeostatic process regulation of stress-activated MAPK cascade positive regulation of stress-activated MAPK cascade regulation of microtubule-based process sterol binding negative regulation of mononuclear cell proliferation protein complex scaffold mitochondrial respiratory chain complex I assembly protein-DNA complex tetrapyrrole metabolic process macromolecule localization regulation of organelle organization regulation of chromosome organization cellular pigmentation mitochondrial respiratory chain complex assembly ER-Golgi intermediate compartment membrane regulation of steroid hormone receptor signaling pathway proton-transporting V-type ATPase complex proton-transporting two-sector ATPase complex- proton-transporting domain proton-transporting two-sector ATPase complex- catalytic domain regulation of cellular amine metabolic process transcription factor TFTC complex monocarboxylic acid binding cholesterol efflux fatty acid beta-oxidation using acyl-CoA oxidase MAP kinase phosphatase activity cellular response to stress unsaturated fatty acid metabolic process response to testosterone stimulus mammary gland epithelial cell proliferation membrane protein proteolysis cell adhesion mediated by integrin regulation of cell adhesion mediated by integrin cellular polysaccharide biosynthetic process DNA polymerase activity RNA polymerase activity CenH3-containing nucleosome assembly at centromere homotypic cell-cell adhesion toll-like receptor 1 signaling pathway toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway activation of protein kinase A activity primary alcohol metabolic process nuclear periphery lipid oxidation microtubule anchoring cellular protein localization cellular response to reactive oxygen species cellular response to unfolded protein cellular macromolecular complex subunit organization ncRNA catabolic process methyltransferase complex DNA replication-independent nucleosome organization negative regulation of transmembrane transport histone lysine methylation response to endoplasmic reticulum stress phosphatidylinositol 3-kinase activity histone acetyltransferase binding sperm-egg recognition methylated histone residue binding phosphatidylinositol binding histone methyltransferase complex embryonic forelimb morphogenesis UDP-galactosyltransferase activity nuclear hormone receptor binding steroid hormone receptor binding multicellular organism growth NuA4 histone acetyltransferase complex regulation of dephosphorylation thioester metabolic process purinergic receptor activity signaling adaptor activity protein deacylation RNA granule modification of morphology or physiology of other organism regulation of multicellular organism growth regulation of epidermal growth factor receptor signaling pathway negative regulation of epidermal growth factor receptor signaling pathway interferon-gamma biosynthetic process positive regulation of T cell proliferation positive regulation of cytokine biosynthetic process negative regulation of T cell proliferation retrograde transport- endosome to Golgi lipoprotein metabolic process lipoprotein biosynthetic process negative regulation of protein catabolic process interleukin-8 biosynthetic process regulation of natural killer cell mediated cytotoxicity ribosomal large subunit biogenesis vasodilation regulation of vasodilation regulation of NF-kappaB import into nucleus positive regulation of NF-kappaB import into nucleus NF-kappaB import into nucleus quinone cofactor metabolic process chemokine receptor binding cilium assembly cellular modified amino acid biosynthetic process cellular biogenic amine catabolic process indole-containing compound metabolic process indole-containing compound catabolic process pigment metabolic process photoreceptor cell development eye photoreceptor cell development melanosome response to hydrogen peroxide myelination superoxide anion generation pteridine-containing compound metabolic process pteridine-containing compound biosynthetic process MHC protein complex ATPase activity- coupled to transmembrane movement of ions mitochondrial nucleoid drug catabolic process hydrogen peroxide metabolic process hydrogen peroxide catabolic process circadian sleep/wake cycle regulation of circadian sleep/wake cycle regulation of circadian rhythm signal transduction in response to DNA damage DNA damage response- signal transduction resulting in transcription ATP synthesis coupled electron transport mitochondrial ATP synthesis coupled electron transport mitochondrial ATP synthesis coupled proton transport protein homooligomerization histone deacetylase binding retinoic acid receptor binding regulation of transcription factor import into nucleus transcription factor import into nucleus positive regulation of transcription factor import into nucleus alpha-tubulin binding gamma-tubulin binding ribonucleoprotein binding ribosome binding caspase inhibitor activity caspase regulator activity T cell homeostasis ATP-dependent chromatin remodeling regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of I-kappaB kinase/NF-kappaB cascade negative regulation of I-kappaB kinase/NF-kappaB cascade negative regulation of caspase activity alcohol binding H4/H2A histone acetyltransferase complex laminin binding negative regulation of protein complex disassembly regulation of protein complex disassembly regulation of protein complex assembly response to morphine positive regulation of caspase activity regulation of caspase activity response to dsRNA negative regulation of DNA binding skeletal muscle tissue regeneration negative regulation of MAPKKK cascade macromolecule glycosylation macromolecule methylation negative regulation of sequence-specific DNA binding transcription factor activity cellular alkene metabolic process alkene biosynthetic process regulation of generation of precursor metabolites and energy regulation of carbohydrate catabolic process regulation of cellular carbohydrate catabolic process pigmentation regulation of RNA stability regulation of mRNA stability RNA stabilization ATPase activity- coupled to movement of substances regulation of protein homodimerization activity eukaryotic cell surface binding muscle adaptation regulation of muscle adaptation regulation of JUN kinase activity positive regulation of JUN kinase activity negative regulation of JUN kinase activity regulation of DNA damage response- signal transduction by p53 class mediator negative regulation of neuron apoptosis positive regulation of neuron apoptosis regulation of insulin-like growth factor receptor signaling pathway peroxisomal transport cellular amide metabolic process protein self-association RNA polyadenylation dicarboxylic acid metabolic process regulation of phosphoprotein phosphatase activity exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay macromolecular complex subunit organization cellular component maintenance histone H4 acetylation histone H2A acetylation cell wall macromolecule metabolic process cellular component biogenesis multicellular organismal catabolic process cellular catabolic process cellular macromolecule catabolic process glycerol ether catabolic process interspecies interaction between organisms chromosomal part mitochondrial part microbody part microtubule-based flagellum part microtubule organizing center part nucleoplasm part nucleolar part nuclear chromosome part mitochondrial membrane part flagellum part purinergic nucleotide receptor activity- G-protein coupled regulation of viral genome replication regulation of interferon-gamma biosynthetic process cellular extravasation establishment of protein localization maintenance of protein location regulation of circadian sleep/wake cycle- sleep isotype switching proton-transporting ATP synthase complex respiratory chain complex I cadherin binding protein phosphorylated amino acid binding clathrin-coated endocytic vesicle MHC class II biosynthetic process type I interferon biosynthetic process fat cell differentiation bone resorption photoreceptor cell maintenance regulation of T cell differentiation positive regulation of T cell differentiation regulation of fat cell differentiation regulation of lymphocyte differentiation positive regulation of lymphocyte differentiation positive regulation of myeloid cell differentiation positive regulation of osteoblast differentiation positive regulation of glial cell differentiation respiratory burst positive regulation of protein catabolic process negative regulation of cyclin-dependent protein kinase activity positive regulation of DNA repair positive regulation of anti-apoptosis negative regulation of blood pressure negative regulation of cell cycle positive regulation of cell cycle positive regulation of cell size positive regulation of endocytosis negative regulation of gene expression- epigenetic negative regulation of heart contraction negative regulation of mitosis negative regulation of mitotic metaphase/anaphase transition pH reduction positive regulation of proteolysis negative regulation of carbohydrate metabolic process positive regulation of growth positive regulation of mitotic cell cycle positive regulation of muscle contraction negative regulation of steroid metabolic process negative regulation of translational initiation positive regulation of natural killer cell mediated cytotoxicity ATP metabolic process purine ribonucleoside metabolic process pyrimidine nucleoside catabolic process pigment biosynthetic process indolalkylamine catabolic process glucose import regulation of glucose import negative regulation of JNK cascade acetyl-CoA catabolic process carboxylic acid catabolic process regulation of JAK-STAT cascade positive regulation of JAK-STAT cascade organophosphate catabolic process icosanoid biosynthetic process prostanoid biosynthetic process neutral lipid catabolic process acylglycerol catabolic process membrane lipid catabolic process phosphatidylinositol metabolic process nicotinamide nucleotide metabolic process glycerolipid catabolic process sphingoid metabolic process glucosyltransferase activity photoreceptor cell differentiation positive regulation of Ras protein signal transduction regulation of viral transcription positive regulation of nucleocytoplasmic transport filopodium assembly bone remodeling intracellular transport transition metal ion transmembrane transporter activity retinoid X receptor binding protein N-terminus binding insulin-like growth factor receptor signaling pathway cofactor binding developmental pigmentation somatic stem cell division regulation of neuronal synaptic plasticity Golgi vesicle transport macrophage chemotaxis mRNA stabilization regulation of receptor-mediated endocytosis positive regulation of receptor-mediated endocytosis vesicle docking organelle fusion organelle fission calcium-dependent protein binding coated membrane autonomic nervous system development enteric nervous system development sympathetic nervous system development beta-tubulin binding synaptic vesicle endocytosis circadian behavior spermatid differentiation negative regulation of behavior positive regulation of viral reproduction thymus development cellular process involved in reproduction regulation of skeletal muscle tissue development muscle organ morphogenesis positive regulation of smooth muscle cell proliferation response to axon injury smooth muscle tissue development pigment granule regulation of dendrite morphogenesis axon extension involved in axon guidance brain morphogenesis homeostasis of number of cells within a tissue chromosome localization positive regulation of viral transcription nucleic acid transport RNA transport flavin adenine dinucleotide binding NADP binding coenzyme binding oxidoreductase activity- acting on NADH or NADPH- oxygen as acceptor negative regulation of lymphocyte proliferation androgen receptor binding interleukin-1 secretion negative regulation of inflammatory response positive regulation of dendrite morphogenesis negative regulation of immune response regulation of viral reproduction circadian sleep/wake cycle- sleep regulation of coagulation regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling T cell receptor signaling pathway negative regulation of B cell activation brown fat cell differentiation multicellular organismal movement musculoskeletal movement intestinal absorption detection of stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception sensory perception of bitter taste negative regulation of chemotaxis pigment cell differentiation detection of mechanical stimulus involved in sensory perception detection of mechanical stimulus regulation of nitric-oxide synthase activity microtubule plus-end binding mRNA transport regulation of membrane protein ectodomain proteolysis negative regulation of DNA metabolic process negative regulation of lipid biosynthetic process positive regulation of small GTPase mediated signal transduction NF-kappaB binding protein tetramerization de novo posttranslational protein folding ATPase binding cofactor metabolic process cofactor catabolic process cofactor biosynthetic process regulation of cofactor metabolic process phosphoprotein binding spindle assembly establishment of RNA localization positive regulation of protein metabolic process protein polymerization protein depolymerization NAD binding protein homotetramerization centrosome organization centrosome duplication cell division establishment of chromosome localization metaphase plate congression attachment of spindle microtubules to chromosome G1 phase S phase meiotic cell cycle anaphase interphase M phase of meiotic cell cycle interphase of mitotic cell cycle regulation of ligase activity regulation of oxidoreductase activity positive regulation of ligase activity negative regulation of ligase activity positive regulation of oxidoreductase activity negative regulation of oxidoreductase activity stress-activated MAPK cascade hormone receptor binding negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle regulation of ubiquitin-protein ligase activity regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity negative regulation of ubiquitin-protein ligase activity intracellular pH reduction regulation of intracellular pH maintenance of protein location in nucleus negative regulation of cytoskeleton organization positive regulation of cytoskeleton organization iron-sulfur cluster binding 4 iron- 4 sulfur cluster binding metal cluster binding histone H3-K9 methylation histone H3-K4 methylation response to electrical stimulus organelle localization nucleus localization vesicle localization establishment of vesicle localization maintenance of location in cell establishment of organelle localization interaction with host interaction with symbiont behavioral interaction between organisms protein phosphatase 2A binding positive regulation of cell division regulation of nuclear division negative regulation of nuclear division response to protein stimulus modification of morphology or physiology of other organism involved in symbiotic interaction modification by host of symbiont morphology or physiology protein autoubiquitination regulation of mitochondrial membrane potential negative regulation of calcium ion transport modulation of transcription in other organism involved in symbiotic interaction nuclear DNA-directed RNA polymerase complex zinc ion homeostasis copper ion homeostasis iron ion homeostasis cilium membrane cilium morphogenesis head development head morphogenesis face development face morphogenesis regulation of cell projection assembly ATPase regulator activity dichotomous subdivision of an epithelial terminal unit tube closure labyrinthine layer development regulation of androgen receptor signaling pathway hepaticobiliary system development membrane fusion regulation of wound healing chaperone-mediated protein folding regulation of protein tyrosine kinase activity macromolecular complex assembly protein-DNA complex assembly aspartic-type peptidase activity threonine-type peptidase activity proline-rich region binding glycosylation protein trimerization protein homotrimerization lymphocyte apoptosis vitamin B6 binding cellular response to hydrogen peroxide negative regulation of stress-activated protein kinase signaling cascade aromatase activity positive regulation of ERK1 and ERK2 cascade SAGA-type complex respiratory chain regulation of microtubule cytoskeleton organization protein K63-linked deubiquitination response to interleukin-1 protein localization in mitochondrion SWI/SNF-type complex negative regulation of leukocyte proliferation cellular macromolecule localization tight junction assembly response to growth factor stimulus E-box binding protein localization in endoplasmic reticulum demethylation oxidative demethylation catalytic step 2 spliceosome histone mRNA catabolic process DNA conformation change regulation of cell cycle arrest positive regulation of cell cycle arrest spindle assembly checkpoint mitotic cell cycle spindle checkpoint cellular response to biotic stimulus cellular response to inorganic substance cellular response to metal ion cellular response to mechanical stimulus cellular response to lithium ion MLL1 complex cellular response to dsRNA cellular response to steroid hormone stimulus cellular response to organic cyclic compound cellular response to protein stimulus cell wall organization or biogenesis npBAF complex zinc ion transmembrane transport transforming growth factor-beta production regulation of transforming growth factor-beta production G1/S transition checkpoint protein-lipid complex binding protein complex subunit organization protein-DNA complex subunit organization cellular component assembly at cellular level neuropeptide receptor binding leukocyte apoptosis nitrogen cycle metabolic process monocarboxylic acid catabolic process primary cilium organelle transport along microtubule signal transduction involved in cell cycle checkpoint signal transduction involved in DNA integrity checkpoint signal transduction involved in G1/S transition checkpoint signal transduction involved in mitotic cell cycle checkpoint signal transduction involved in DNA damage checkpoint signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint signal transduction involved in mitotic cell cycle G1/S checkpoint divalent inorganic cation transmembrane transporter activity pyridine-containing compound metabolic process pyrimidine-containing compound catabolic process establishment of protein localization to organelle maintenance of protein localization to organelle establishment of protein localization in mitochondrion protein localization in membrane protein localization in plasma membrane protein localization to peroxisome establishment of protein localization to peroxisome CUL4 RING ubiquitin ligase complex establishment of protein localization in plasma membrane regulation of establishment of protein localization in plasma membrane negative regulation of transcription regulator activity positive regulation of cell cycle process foam cell differentiation positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway establishment of protein localization in membrane positive regulation of peptide hormone secretion nucleic acid phosphodiester bond hydrolysis positive regulation of intracellular protein transport regulation of DNA-dependent DNA replication mitochondrial respiratory chain complex I biogenesis regulation of G1/S transition of mitotic cell cycle negative regulation of DNA-dependent DNA replication regulation of reproductive process negative regulation of reproductive process positive regulation of reproductive process regulation of interphase of mitotic cell cycle ureteric bud development negative regulation of protein phosphorylation anchored to plasma membrane lysosomal membrane early endosome vacuolar membrane Golgi stack glucose catabolic process generation of precursor metabolites and energy oxidoreductase activity protein targeting regulation of pH response to osmotic stress response to oxidative stress regulation of G-protein coupled receptor protein signaling pathway response to radiation endosome membrane mesenchymal cell proliferation regulation of mesenchymal cell proliferation monovalent inorganic cation transmembrane transporter activity antiporter activity carbohydrate catabolic process phosphatase activity ligase activity ligase activity- forming carbon-nitrogen bonds kinase inhibitor activity hexose biosynthetic process hexose catabolic process inorganic cation transmembrane transporter activity regulation of nucleotide catabolic process intrinsic to organelle membrane integral to organelle membrane positive regulation of defense response regulation of ARF protein signal transduction regulation of purine nucleotide catabolic process protein localization to organelle carbohydrate homeostasis protein localization to nucleus regulation of cytokine biosynthetic process cytokine biosynthetic process cytokine metabolic process glucose homeostasis regulation of protein binding cellular protein complex assembly cellular carbohydrate catabolic process vacuolar part endosomal part positive regulation of DNA replication positive regulation of angiogenesis GTP metabolic process alcohol catabolic process monosaccharide catabolic process regulation of sequence-specific DNA binding transcription factor activity positive regulation of sequence-specific DNA binding transcription factor activity regulation of binding positive regulation of protein transport recycling endosome regulation of stress-activated protein kinase signaling cascade regulation of cellular response to stress regulation of transcription regulator activity positive regulation of transcription regulator activity ovarian follicle development positive regulation of cytokine production tissue homeostasis myeloid leukocyte activation protein import into nucleus cytokine activity cytokine receptor binding steroid binding female gonad development protein secretion protein processing cellular component disassembly ovulation cycle process negative regulation of intracellular transport tube formation cholesterol homeostasis ovulation cycle cell cortex part regulation of innate immune response phosphatidylcholine metabolic process homeostasis of number of cells cytokine secretion regulation of protein secretion positive regulation of protein secretion nuclear import protein maturation sterol homeostasis artery development ovum-producing ovary development regulation of biomineral tissue development cellular response to abiotic stimulus glucuronosyltransferase activity oxidoreductase activity- acting on single donors with incorporation of molecular oxygen- incorporati transferase activity- transferring hexosyl groups protein import response to type I interferon cellular respiration dioxygenase activity type I interferon-mediated signaling pathway cellular response to type I interferon ribosome biogenesis DNA replication NAD+ ADP-ribosyltransferase activity DNA metabolic process translation regulation of translation nucleocytoplasmic transport cellular component disassembly involved in apoptosis glycoprotein metabolic process glycoprotein biosynthetic process chromatin modification nuclear body lyase activity negative regulation of translation negative regulation of cellular protein metabolic process structure-specific DNA binding nuclear transport negative regulation of protein metabolic process response to calcium ion glycerophospholipid metabolic process ARF GTPase activator activity phospholipid biosynthetic process sterol metabolic process organophosphate metabolic process regulation of ARF GTPase activity glycerolipid biosynthetic process glycerolipid metabolic process negative regulation of nucleocytoplasmic transport regulation of response to cytokine stimulus negative regulation of intracellular protein transport regulation of mitotic cell cycle monooxygenase activity endopeptidase inhibitor activity transmembrane receptor activity G-protein coupled receptor activity extracellular matrix structural constituent detection of external stimulus endopeptidase regulator activity peptidase inhibitor activity peptidase regulator activity aldo-keto reductase (NADP) activity endoplasmic reticulum membrane estrogen metabolic process response to carbohydrate stimulus lipid catabolic process nuclear outer membrane-endoplasmic reticulum membrane network response to cholesterol cellular response to carbohydrate stimulus cellular response to monosaccharide stimulus cellular response to hexose stimulus cellular response to glucose stimulus intermediate filament defense response to bacterium olfactory receptor activity fibroblast growth factor receptor binding hormone activity C21-steroid hormone biosynthetic process single fertilization sensory perception sensory perception of chemical stimulus sensory perception of smell C21-steroid hormone metabolic process regulation of carbohydrate biosynthetic process keratin filament intermediate filament cytoskeleton modification-dependent protein catabolic process organellar large ribosomal subunit nucleotide-excision repair- DNA damage removal embryonic epithelial tube formation damaged DNA binding glutathione transferase activity aminoacyl-tRNA ligase activity ubiquitin-protein ligase activity protein kinase inhibitor activity protein ubiquitination mitochondrial envelope mitochondrial large ribosomal subunit smooth endoplasmic reticulum lipid particle DNA repair poly(A) RNA binding tRNA metabolic process tRNA aminoacylation for protein translation protein ADP-ribosylation proteolysis proteolysis involved in cellular protein catabolic process ubiquitin-dependent protein catabolic process microtubule-based process proteasomal protein catabolic process ligase activity- forming carbon-oxygen bonds ligase activity- forming aminoacyl-tRNA and related compounds acid-amino acid ligase activity AU-rich element binding small conjugating protein ligase activity viral reproductive process integral to endoplasmic reticulum membrane intrinsic to endoplasmic reticulum membrane negative regulation of protein modification process mitochondrial membrane protein modification by small protein conjugation positive regulation of type I interferon production positive regulation of interferon-beta production ncRNA metabolic process cilium axoneme ribosome assembly ribosomal small subunit biogenesis amino acid activation tRNA aminoacylation proteasomal ubiquitin-dependent protein catabolic process positive regulation of DNA binding modification-dependent macromolecule catabolic process cellular protein catabolic process cilium part regulation of mRNA processing positive regulation of binding regulation of DNA binding protein K63-linked ubiquitination protein modification by small protein conjugation or removal poly-purine tract binding cellular response to glucagon stimulus epithelial tube formation positive regulation of mesenchymal cell proliferation regulation of BMP signaling pathway nuclear envelope transforming growth factor beta receptor signaling pathway oxidoreductase activity- acting on CH-OH group of donors retinoid metabolic process microsome terpenoid metabolic process fat-soluble vitamin metabolic process vitamin A metabolic process regulation of cellular ketone metabolic process diterpenoid metabolic process secondary metabolic process vesicular fraction regulation of peptidase activity cellular glucose homeostasis desmosome hormone binding tetrapyrrole binding artery morphogenesis triglyceride homeostasis heme binding odontogenesis of dentine-containing tooth anatomical structure homeostasis positive regulation of stress-activated protein kinase signaling cascade ATP-dependent helicase activity regulation of protein export from nucleus purine NTP-dependent helicase activity positive regulation of DNA metabolic process cytosolic small ribosomal subunit single-stranded RNA binding structural constituent of ribosome ribosome glycolysis translational elongation translational termination covalent chromatin modification histone modification viral infectious cycle viral genome expression viral transcription cytosolic ribosome pancreas development endocrine pancreas development macromolecular complex disassembly cellular macromolecular complex disassembly endocrine system development protein complex disassembly cellular protein complex disassembly cellular component disassembly at cellular level heart looping embryonic heart tube morphogenesis erythrocyte homeostasis determination of heart left/right asymmetry response to virus positive regulation of catabolic process cation:cation antiporter activity carbohydrate biosynthetic process chemokine production cellular carbohydrate biosynthetic process positive regulation of innate immune response positive regulation of NF-kappaB transcription factor activity cysteine-type peptidase activity gluconeogenesis regulation of carbohydrate metabolic process cellular defense response regulation of cellular carbohydrate metabolic process response to lipid alcohol biosynthetic process monosaccharide biosynthetic process response to cAMP protein acylation SMAD binding solute:solute antiporter activity nucleobase- nucleoside- nucleotide kinase activity monovalent inorganic cation homeostasis pyrimidine nucleoside metabolic process mitochondrial transport nucleoside triphosphate biosynthetic process regulation of chemokine production negative regulation of cytokine biosynthetic process neutral lipid metabolic process acylglycerol metabolic process triglyceride metabolic process glycerol ether metabolic process JAK-STAT cascade organic ether metabolic process glycerophospholipid biosynthetic process protein heterooligomerization protein polyubiquitination regulation of cytokine-mediated signaling pathway regulation of RNA splicing GTP binding nucleoside metabolic process oxidoreductase activity- acting on a sulfur group of donors peptidyl-lysine modification guanyl nucleotide binding guanyl ribonucleotide binding branching involved in ureteric bud morphogenesis response to organic nitrogen ureteric bud morphogenesis metalloendopeptidase activity regulation of striated muscle tissue development negative regulation of BMP signaling pathway regulation of developmental growth male gonad development regulation of muscle organ development cellular response to lipid inactivation of MAPK activity isoprenoid metabolic process retinol metabolic process peptidase activity- acting on L-amino acid peptides response to toxin negative regulation of peptidase activity negative regulation of endopeptidase activity response to fungus multicellular organismal metabolic process structural molecule activity nuclear speck cell differentiation in hindbrain post-translational protein modification retinol dehydrogenase activity amino sugar metabolic process glucosamine metabolic process N-acetylglucosamine metabolic process phosphatidylcholine biosynthetic process energy derivation by oxidation of organic compounds oxidoreductase activity- acting on the CH-OH group of donors- NAD or NADP as acceptor organelle inner membrane organ regeneration interferon-alpha production regulation of interferon-alpha production steroid dehydrogenase activity- acting on the CH-OH group of donors- NAD or NADP as acceptor ethanolamine-containing compound metabolic process regulation of lipoprotein lipase activity protein K11-linked ubiquitination response to glucagon stimulus polysaccharide catabolic process phospholipase inhibitor activity protein kinase A binding glycerol metabolic process steroid catabolic process steroid hydroxylase activity microtubule-based flagellum regulation of collagen metabolic process solute:cation antiporter activity transferase activity- transferring sulfur-containing groups hydrolase activity- acting on carbon-nitrogen (but not peptide) bonds- in linear amides alditol metabolic process flagellum hindbrain morphogenesis cerebellum morphogenesis sperm motility positive regulation of chemokine production cellular response to oxidative stress macrophage activation response to amino acid stimulus regulation of multicellular organismal metabolic process monosaccharide binding lipase inhibitor activity positive regulation of JNK cascade negative regulation of gliogenesis ncRNA processing protein acetylation internal protein amino acid acetylation protein export from nucleus histone acetylation internal peptidyl-lysine acetylation peptidyl-lysine acetylation cellular macromolecular complex assembly nuclear export ubiquitin thiolesterase activity microtubule-based movement purine ribonucleoside triphosphate biosynthetic process cholesterol metabolic process embryonic digit morphogenesis organellar ribosome helicase activity Ada2/Gcn5/Ada3 transcription activator complex mitochondrial ribosome pyrimidine nucleotide biosynthetic process CTP biosynthetic process bile acid biosynthetic process bile acid metabolic process exopeptidase activity pyrimidine nucleoside triphosphate metabolic process pyrimidine nucleoside triphosphate biosynthetic process pyrimidine ribonucleoside triphosphate metabolic process pyrimidine ribonucleoside triphosphate biosynthetic process pyrimidine ribonucleotide metabolic process pyrimidine ribonucleotide biosynthetic process nucleobase- nucleoside and nucleotide interconversion phosphotransferase activity- phosphate group as acceptor polyol metabolic process CTP metabolic process ATPase activity- coupled mRNA processing determination of left/right symmetry specification of symmetry determination of bilateral symmetry embryonic heart tube development unfolded protein binding RNA splicing- via transesterification reactions RNA splicing- via transesterification reactions with bulged adenosine as nucleophile nuclear mRNA splicing- via spliceosome proteasome complex protein folding DNA catabolic process RNA splicing regulation of proteasomal protein catabolic process organ growth positive regulation of cytokine secretion regulation of type I interferon-mediated signaling pathway protein import into nucleus- translocation response to starvation mitochondrial outer membrane outer membrane organelle outer membrane hydrolase activity- hydrolyzing O-glycosyl compounds hydrolase activity- acting on glycosyl bonds regulation of proteolysis biomineral tissue development regulation of DNA replication response to amine stimulus antioxidant activity response to acid taste receptor activity cell surface binding negative regulation of proteolysis regulation of cytokine secretion negative regulation of hydrolase activity negative regulation of protein binding nucleotide-excision repair negative regulation of binding purine nucleoside triphosphate biosynthetic process ribonucleoside triphosphate biosynthetic process regulation of proteasomal ubiquitin-dependent protein catabolic process recycling endosome membrane regulation of kidney development positive regulation of kidney development electron carrier activity mitochondrial intermembrane space electron transport chain protein maturation by peptide bond cleavage oxidoreductase activity- acting on NADH or NADPH organelle envelope lumen small conjugating protein binding interferon-beta production regulation of interferon-beta production purine ribonucleotide biosynthetic process translation regulator activity ribonucleotide biosynthetic process cellular lipid catabolic process regulation of protein catabolic process histone acetyltransferase complex single-stranded DNA binding peptidyl-prolyl cis-trans isomerase activity peroxisome mitochondrial inner membrane mitochondrial matrix base-excision repair rRNA processing translational initiation acyltransferase activity protein transporter activity aerobic respiration large ribosomal subunit small ribosomal subunit rRNA metabolic process transferase activity- transferring acyl groups transferase activity- transferring acyl groups other than amino-acyl groups isomerase activity cis-trans isomerase activity heat shock protein binding ribonucleoprotein complex biogenesis ribonucleoprotein complex assembly polyubiquitin binding microbody ubiquitin binding histone H3 acetylation cytosolic part regulation of DNA metabolic process ribonucleoprotein complex subunit organization cellular component biogenesis at cellular level organelle assembly transferase activity- transferring pentosyl groups disulfide oxidoreductase activity mRNA binding ubiquitin-specific protease activity trans-Golgi network cilium cell redox homeostasis pyrimidine nucleotide metabolic process regulation of translational initiation steroid biosynthetic process gamete generation spermatogenesis sensory perception of taste ribonucleoside metabolic process fertilization protein disulfide oxidoreductase activity hydrogen ion transmembrane transporter activity positive regulation of translation steroid dehydrogenase activity protein deubiquitination transferase activity- transferring alkyl or aryl (other than methyl) groups thiolester hydrolase activity intramolecular oxidoreductase activity intramolecular oxidoreductase activity- transposing C=C bonds small conjugating protein-specific protease activity sexual reproduction early endosome membrane regulation of type I interferon production type I interferon production pyrimidine ribonucleoside metabolic process regulation of organ growth male gamete generation protein modification by small protein removal protein K48-linked ubiquitination pyrimidine-containing compound metabolic process pyrimidine-containing compound biosynthetic process intramolecular oxidoreductase activity, interconverting keto- and enol-groups regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process nucleotide-excision repair, DNA damage removal positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process positive regulation of transcription, DNA-dependent protein binding, bridging 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process transcription, DNA-dependent regulation of transcription, DNA-dependent transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor nucleobase, nucleoside, nucleotide and nucleic acid catabolic process nucleobase, nucleoside and nucleotide catabolic process negative regulation of transcription, DNA-dependent negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process nucleobase, nucleoside and nucleotide metabolic process binding, bridging DNA damage response, signal transduction resulting in induction of apoptosis hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides oxidoreductase activity, acting on peroxide as acceptor regulation of synaptic transmission, GABAergic synaptic transmission, GABAergic alternative nuclear mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process, exonucleolytic nuclear chromosome, telomeric region nucleotide receptor activity, G-protein coupled purinergic nucleotide receptor activity, G-protein coupled translation factor activity, nucleic acid binding oxidoreductase activity, acting on a sulfur group of donors exoribonuclease activity, producing 5'-phosphomonoesters blood coagulation, intrinsic pathway blood coagulation, fibrin clot formation G-protein signaling, coupled to cAMP nucleotide second messenger hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines nucleobase, nucleoside, nucleotide and nucleic acid transport retrograde transport, endosome to Golgi intramolecular oxidoreductase activity, interconverting aldoses and ketoses phosphatidylinositol-3,4,5-trisphosphate binding Wnt receptor signaling pathway, calcium modulating pathway hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides intramolecular transferase activity, phosphotransferases G-protein signaling, coupled to cyclic nucleotide second messenger peptide receptor activity, G-protein coupled synaptic transmission, glutamatergic synaptic transmission, dopaminergic transforming growth factor beta receptor, cytoplasmic mediator activity DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger synaptic transmission, cholinergic 2'-deoxyribonucleotide metabolic process oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor oxidoreductase activity, acting on the CH-NH2 group of donors oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on CH or CH2 groups transferase activity, transferring amino-acyl groups hydrolase activity, acting on ester bonds regulation of synaptic transmission, dopaminergic nucleobase, nucleoside and nucleotide biosynthetic process nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process DNA damage response, signal transduction resulting in transcription positive regulation of CD4-positive, alpha-beta T cell differentiation 3',5'-cyclic-GMP phosphodiesterase activity elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger 2 iron, 2 sulfur cluster binding positive regulation of CD4-positive, alpha-beta T cell activation symbiosis, encompassing mutualism through parasitism Wnt receptor signaling pathway, planar cell polarity pathway regulation of gene expression, epigenetic transferase activity, transferring glycosyl groups hydrolase activity, hydrolyzing N-glycosyl compounds circadian sleep/wake cycle, sleep protein import into nucleus, translocation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay proton-transporting ATPase activity, rotational mechanism DNA catabolic process, endonucleolytic condensed nuclear chromosome, centromeric region CD4-positive, alpha-beta T cell differentiation involved in immune response mRNA 3'-UTR binding hydrogen ion transporting ATP synthase activity, rotational mechanism retrograde vesicle-mediated transport, Golgi to ER phagocytosis, engulfment phototransduction, visible light 3'-5' exonuclease activity peptidase activity, acting on L-amino acid peptides nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity nucleobase, nucleoside and nucleotide interconversion energy coupled proton transport, against electrochemical gradient oxidoreductase activity, acting on the CH-NH group of donors oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen transferase activity, transferring nitrogenous groups endoribonuclease activity, producing 3'-phosphomonoesters proton-transporting two-sector ATPase complex, catalytic domain phosphatidylinositol-3,4-bisphosphate binding CD4-positive, alpha-beta T cell differentiation regulation of CD4-positive, alpha-beta T cell differentiation regulation of DNA damage response, signal transduction by p53 class mediator regulation of symbiosis, encompassing mutualism through parasitism 3'-phosphoadenosine 5'-phosphosulfate metabolic process oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor regulation of synaptic transmission, glutamatergic regulation of CD4-positive, alpha-beta T cell activation nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay RNA splicing, via transesterification reactions RNA splicing, via transesterification reactions with bulged adenosine as nucleophile nuclear mRNA splicing, via spliceosome chromosome, centromeric region condensed chromosome, centromeric region ATPase activity, coupled DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest transferase activity, transferring hexosyl groups ligase activity, forming carbon-oxygen bonds ligase activity, forming aminoacyl-tRNA and related compounds ligase activity, forming carbon-nitrogen bonds DNA damage response, signal transduction by p53 class mediator DNA-directed RNA polymerase II, holoenzyme ATPase activity, coupled to transmembrane movement of substances hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances ATPase activity, coupled to movement of substances adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds phosphatidylinositol-3,5-bisphosphate binding DNA-directed RNA polymerase II, core complex proton-transporting ATP synthase complex, coupling factor F(o) complement activation, alternative pathway energy coupled proton transport, down electrochemical gradient exodeoxyribonuclease activity, producing 5'-phosphomonoesters regulation of transcription initiation, DNA-dependent transferase activity, transferring pentosyl groups chromosome, telomeric region phosphatidylinositol-4,5-bisphosphate binding nucleotide-excision repair, DNA gap filling transcription initiation, DNA-dependent transcription termination, DNA-dependent 'de novo' protein folding complement activation, classical pathway ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism oxidoreductase activity, acting on NADH or NADPH oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor oxidoreductase activity, acting on a heme group of donors oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor oxidoreductase activity, acting on single donors with incorporation of molecular oxygen oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors oxidoreductase activity, oxidizing metal ions transferase activity, transferring one-carbon groups transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, phosphate group as acceptor phosphotransferase activity, for other substituted phosphate groups transferase activity, transferring sulfur-containing groups exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines intramolecular oxidoreductase activity, transposing C=C bonds ligase activity, forming carbon-sulfur bonds endoribonuclease activity, producing 5'-phosphomonoesters endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters nucleobase, nucleoside, nucleotide kinase activity RNA 3'-end processing mRNA 3'-end processing steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor CD4-positive, alpha-beta T cell activation ATPase activity, coupled to transmembrane movement of ions DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis regulation of circadian sleep/wake cycle, sleep negative regulation of gene expression, epigenetic vesicle targeting, to, from or within Golgi 'de novo' posttranslational protein folding 4 iron, 4 sulfur cluster binding transcription elongation, DNA-dependent oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen regulation of transcription elongation, DNA-dependent oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor proton-transporting two-sector ATPase complex, proton-transporting domain transferase activity, transferring alkyl or aryl (other than methyl) groups hydrolase activity, hydrolyzing O-glycosyl compounds oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors hydrolase activity, acting on glycosyl bonds